Hexahydro-1,4-diazepine → HCID 10169463, compound

HRID 993023Notes

Reaction equation

HRID 993023 reaction equation
Cl[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[N:5]([CH2:20][C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[N:4]=1.[NH:27]1[CH2:33][CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[N:23]1[CH:24]=[CH:25][CH:26]=[C:21]([CH2:20][N:5]2[C:6]([C:8]3[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=3)=[CH:7][C:3]([CH2:2][N:27]3[CH2:33][CH2:32][CH2:31][N:30]([CH2:2][C:3]4[CH:7]=[C:6]([C:8]5[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=5)[N:5]([CH2:20][C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)[N:4]=4)[CH2:29][CH2:28]3)=[N:4]2)[CH:22]=1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 18408514HCID 18408514, compound

Product 1

HCID 10169463HCID 10169463, compound

Procedure

3-Chloromethyl-1-(3-pyridylmethyl)-5-(3,4,5-trimethoxyphenyl)pyrazole (110 mg) and homopiperazine (13 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-b2a5ed7ca7f1497ea97e7733e8674d6e
Source dataset
uspto-grants-2002_10
Patent number
US06472386B1

Reaction notes

Loading…