Tetrabutylammonium Fluoride → HCID 67524575, compound

Participants

Reaction Steps

O-tert-Butyldimethylsilyl-N-(3,4,5-trimethoxy-benzoyl)-L-serine methyl ester (15.91 g) was dissolved in THF (70 mL), and to the solution a THF solution (55.82 mL) of 1.0 M tetrabutylammonium fluoride was added at 0° C., and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resultant crude crystals were then recrystallized from methanol-ether-hexane to obtain the title compound.

Provenance & Evidence