反应详情

A mixture of 5-[3-(4-Methoxyphenyl)propyl]barbituric Acid (2.5 g), N-bromosuccinimide (2 g) and dibenzoyl peroxide (catalytic amount) in 110 ml of carbon tetrachloride is refluxed for about 1 hour, then the solid which separated is filtered. The solid is redissolved in ethyl acetate and filtered through a silica gel cake in order to eliminate the succinimide residue. The organic phase is then concentrated to dryness and the residue is crystallized from diethylether/carbon tetrachloride mixture. A pale yellow solid separates which is filtered and dried under vacuum at 60° C. to give 2.8 g of the product, m.p. 113-114° C.

1. temperatureis refluxed for about 1 hour
2. customthe solid which separated
3. filtrationis filtered
4. dissolutionThe solid is redissolved in ethyl acetate
5. filtrationfiltered through a silica gel cake in order
6. concentrationThe organic phase is then concentrated to dryness
7. customthe residue is crystallized from diethylether/carbon tetrachloride mixture
8. filtrationA pale yellow solid separates which is filtered
9. customdried under vacuum at 60° C.