HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-Phenyl-5-[4-(2-hydroxyethylidene)piperidinyl]barbituric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Bromo-5-phenyl-barbiturate | HCID 10858987 | — |
| Reactant | 2-(Piperidin-4-ylidene)ethan-1-ol | HCID 18695533 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Phenyl-5-[4-(2-hydroxyethylidene)piperidinyl]barbituric acid | HCID 18408651 | 16.5% |
Reaction Steps
A mixture of 5-Bromo-5-phenylbarbituric Acid (2.45 g), 4-(hydroxyethylidene)piperidine (1.053 g) and triethylamine (1.15 ml) in 50 ml of ethanol is refluxed for 2 hours. The solvent is evaporated under reduced pressure and the residue is purified by silica gel chromatography (40 g; eluent: ethyl acetate/petroleum ether 8:2), to give 450 mg of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472396B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-a6880f49e0574430a9a9ba2c83271919 |
| Source note | uspto-grants-2002_10 |