HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)piperazine → HCID 54241940, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 1380839 | HCID 1380839 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54241940 | HCID 54241940 | — |
Reaction Steps
A solution of 5-Bromo-5-benzylbarbituric Acid (2.15 g) and N-(2-hydroxyethyl)piperazine in 50 ml of ethanol is refluxed for 4 hours, then it is cooled to room temperature and added with 4 ml of triethylamine. The solvent is evaporated off and the white residue is redissolved in a ethyl acetate/methanol 3:1 mixture. An ornage solid crystallizes, which is recovered by filtration. After recrystallization from ethanol 0.62 g of the product are obtained, m.p. 243-246° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472396B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-458eb6257ac44db7861e398388dd95d0 |
| Source note | uspto-grants-2002_10 |