HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Bromo-5-(4'-phenoxyphenyl)barbituric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5-(4-Phenoxyphenyl)-1,3-diazinane-2,4,6-trione | HCID 11673778 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-5-(4'-phenoxyphenyl)barbituric acid | HCID 22732233 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a suspension of 5-(4′-phenoxyphenyl)barbituric Acid (48 mg) in 0.23 ml of water, cooled at 0° C. and under stirring, are added 23 ml of 48% hydrobromic acid and successively 9 μl of bromine. After 2 hours at room temperature additional 9 μl of bromine are added and stirring is continued for 2 hours. The suspended solid is then filtered and washed with water, to give, after drying under vacuum at 60° C., 57 mg of the product, m.p. 125-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472396B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-899d979c058943989dad4a8cba3bcd22 |
| Source note | uspto-grants-2002_10 |