(2-(2-Methoxyethoxy)ethoxy)acetic acid → HCID 10234628, compound

HRID 993145Notes

Reaction equation

[C:1]([NH:5][C:6]([C@@H:8]1[CH2:17][C@H:16]2[C@H:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:10][N:9]1[CH2:18][C@@H:19]([OH:50])[C@@H:20]([NH:28][C:29](=[O:49])[C@H:30]([C:42]([S:45]([CH3:48])(=[O:47])=[O:46])([CH3:44])[CH3:43])[NH:31][C:32](=[O:41])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]#[N:40])[CH:34]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:51][O:52][CH2:53][CH2:54][O:55][CH2:56][CH2:57][O:58][CH2:59][C:60](O)=[O:61]>>[C:1]([NH:5][C:6]([C@@H:8]1[CH2:17][C@H:16]2[C@H:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:10][N:9]1[CH2:18][C@@H:19]([O:50][C:60](=[O:61])[CH2:59][O:58][CH2:57][CH2:56][O:55][CH2:54][CH2:53][O:52][CH3:51])[C@@H:20]([NH:28][C:29](=[O:49])[C@H:30]([C:42]([S:45]([CH3:48])(=[O:46])=[O:47])([CH3:44])[CH3:43])[NH:31][C:32](=[O:41])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]#[N:40])[CH:34]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 85241(2-(2-Methoxyethoxy)ethoxy)acetic acid

HCID 10305604HCID 10305604, compound

Product 1

HCID 10234628HCID 10234628, compound

Procedure

Example 160, [M+H]+ 868.5, was prepared in a manner analogous to Example 147 starting from N-tert-butyl-2-[3(S)-[[N-(3-cyanobenzoyl)-3-(methanesulfonyl)-L-valyl]amino]-2(R)-hydroxy-4-phenylbutyl]-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydro-3(S)-isoquinolinecarboxamide (Example 39) and 2-[2-(2-methoxyethoxy)ethoxy]acetic acid (Aldrich 40,7000-3).

Sources & evidence

ORD record: ord-d5abfc938b154d939bf9fe4f3f6618a1
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06472404B1

Reaction notes

Loading…