HRID993145

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85241

(2-(2-Methoxyethoxy)ethoxy)acetic acid

C7H14O5

结构：CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cccc(C#N)c1)C(C)(C)S(C)(=O)=O

HCID10305604

未命名化合物

PRODUCTS

生成物

结构：COCCOCCOCC(=O)O[C@H](CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cccc(C#N)c1)C(C)(C)S(C)(=O)=O

HCID10234628

未命名化合物

PROCEDURE

实验过程

Example 160, [M+H]+ 868.5, was prepared in a manner analogous to Example 147 starting from N-tert-butyl-2-[3(S)-[[N-(3-cyanobenzoyl)-3-(methanesulfonyl)-L-valyl]amino]-2(R)-hydroxy-4-phenylbutyl]-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydro-3(S)-isoquinolinecarboxamide (Example 39) and 2-[2-(2-methoxyethoxy)ethoxy]acetic acid (Aldrich 40,7000-3).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5abfc938b154d939bf9fe4f3f6618a1
来源数据集: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06472404B1
来源说明: uspto-grants-2002_10

反应 SMILES

[C:1]([NH:5][C:6]([C@@H:8]1[CH2:17][C@H:16]2[C@H:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:10][N:9]1[CH2:18][C@@H:19]([OH:50])[C@@H:20]([NH:28][C:29](=[O:49])[C@H:30]([C:42]([S:45]([CH3:48])(=[O:47])=[O:46])([CH3:44])[CH3:43])[NH:31][C:32](=[O:41])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]#[N:40])[CH:34]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:51][O:52][CH2:53][CH2:54][O:55][CH2:56][CH2:57][O:58][CH2:59][C:60](O)=[O:61]>>[C:1]([NH:5][C:6]([C@@H:8]1[CH2:17][C@H:16]2[C@H:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:10][N:9]1[CH2:18][C@@H:19]([O:50][C:60](=[O:61])[CH2:59][O:58][CH2:57][CH2:56][O:55][CH2:54][CH2:53][O:52][CH3:51])[C@@H:20]([NH:28][C:29](=[O:49])[C@H:30]([C:42]([S:45]([CH3:48])(=[O:46])=[O:47])([CH3:44])[CH3:43])[NH:31][C:32](=[O:41])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]#[N:40])[CH:34]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]