HCID 11372216, compound → HCID 11260252, compound

HRID 993175Notes

Reaction equation

HRID 993175 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.C(OC(N1CCN(C2[C:50]3[C:45](=[CH:46][C:47](F)=[C:48](F)[CH:49]=3)[N:44]=CN=2)CC1)=O)(C)(C)C>>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][CH:15]=[C:14]2[N:11]1[CH2:12][CH2:13][N:8]([C:6]([NH:44][C:45]2[CH:46]=[CH:47][C:48]([O:24][C:21]3[CH:22]=[CH:23][CH:18]=[CH:19][CH:20]=3)=[CH:49][CH:50]=2)=[O:7])[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 11372216HCID 11372216, compoundHCID 54134689HCID 54134689, compound

Product 1

HCID 11260252HCID 11260252, compoundYield 57%

Procedure

Substantially the same procedure as in Example 329 was repeated, except that 4-(6,7-dimethoxy-4-quinolyl)-1-piperazinecarboxylic acid tert-butyl ester obtained in Reference Example 17 was used in place of 4-(6,7-difluoro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester, to give the desired compound.

Workup

  1. customobtained in Reference Example 17

Sources & evidence

ORD record
ord-8cc47824aa7648bea7fecebf03bdbd84
Source dataset
uspto-grants-2002_10
Patent number
US06472391B2

Reaction notes

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