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Ethyl Acetate → 4-Amino-1-Boc-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 1,1-Dimethylethyl 4-azido-1-piperidinecarboxylate | HCID 11458794 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Amino-1-Boc-piperidine | HCID 1268291 | 97.6% |
反応手順
A solution of 4.05 g (17.9 mmol) of 4-azido-1-t-butoxycarbonylpiperidine from Step A in 50 mL of methanol was hydrogenated with 350 mg of 10% Pd/C under a hydrogen balloon for 16 h when the reaction was complete by TLC (10% ethyl acetate in hexanes). The catalyst was filtered off and the volatiles removed in vacuo to give 3.5 g of title compound which was used directly in subsequent reactions.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06472410B1 |
| 出典データセット | uspto-grants-2002_10 |
| ORD ID | ord-54d619ab1aa34617b48d764eee84bdbe |
| 出典メモ | uspto-grants-2002_10 |