HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 2-Chloro-6-methoxybenzeneacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 2-(Bromomethyl)-1-chloro-3-methoxybenzene | HCID 22327443 | — |
| Catalyst | Trioctylmethylammonium chloride | HCID 21218 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Chloro-6-methoxybenzeneacetonitrile | HCID 22327511 | 87.3% |
Reaction Steps
483 g of 2-chloro-6-methoxybenzyl bromide in 410 ml of toluene are reacted with 131 g of sodium cyanide in 132 ml of water and 3.28 g of Aliquat 336. 325 g of colorless oil are obtained (b.p. 103° C./0.08 mbar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472419B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-4edb608b1fa74411b5f678fece3934bd |
| Source note | uspto-grants-2002_10 |