HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 4-Chloro-2-methylbenzeneacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-(Bromomethyl)-4-chloro-2-methoxybenzene | HCID 22327474 | — |
| Catalyst | Trioctylmethylammonium chloride | HCID 21218 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-2-methylbenzeneacetonitrile | HCID 18409934 | — |
Reaction Steps
269 g of 4-chloro-2-methoxybenzyl bromide in 214 ml of toluene are reacted with 68.2 g of sodium cyanide in 69 ml of water and 1.8 g of Aliquat 336. 141 g of colorless oil are obtained (b.p. 107° C./0.08 mbar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472419B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-8a7fba9245b44deb9fec596dd436d4de |
| Source note | uspto-grants-2002_10 |