HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → (2-Chloro-4-methoxyphenyl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 1-(Bromomethyl)-2-chloro-4-methoxybenzene | HCID 22327428 | — |
| Catalyst | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Chloro-4-methoxyphenyl)acetonitrile | HCID 22327506 | 96% |
Reaction Steps
212 g (purity 82%) of 2-chloro-4-methoxybenzyl bromide in 900 ml of dichloromethane are reacted in the course of 4 h at 40° C. with 176 g of potassium cyanide in 675 ml of water and 15.5 g of tetrabutylammonium hydrogen sulfate. After working-up, 157 g of brownish oil are obtained (purity 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472419B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-215da3fea9de4af8b4d6778b40fb0980 |
| Source note | uspto-grants-2002_10 |