HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (2-Chloro-4-methoxyphenyl)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(2-Chloro-4-methoxyphenyl)acetic acid | HCID 4209132 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (2-Chloro-4-methoxyphenyl)acetyl chloride | HCID 22327520 | — |
Reaction Steps
160 g of 2-chloro-4-methoxyphenylacetic acid are suspended in 210 ml of toluene, and the suspension is stirred together with 96 ml of thionyl chloride at 80° C. until the evolution of gas has ceased. The volatile components are stripped off, and the residue is distilled. 90 g of an orange oil are obtained (thin-film evaporator 170° C., 0.08 mbar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06472419B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-0ee89368526f46f4ae24d850a0f783e7 |
| Source note | uspto-grants-2002_10 |