Aluminium lithium hydride → 1-(3-Pyridinyl)cyclopropanemethanol

Participants

Reaction Steps

To a cooled (−78° C.) solution of 7-2 (76 g, 398 mmol) in 500 mL THF was added LiAlH4 (1.0M, 250 mL, 250 mmol) gradually. The reaction mixture was stirred for 2 hr and quenched sequentially with 9.5 mL H2O, 9.5 mL 15% NaOH, and 28.5 mL H2O. The mixture was stirred overnight. Celite (50 g) was added and the mixture stirred for 20 min and filtered through a silica gel plug and concentrated to afford the desired product 7-3 as an oil which was used in the next step without further purification.

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