Cyclopentanol → HCID 22145838, compound

Participants

Reaction Steps

6-Chloro-5-methoxypyridine-2-carbonyl chloride (5.8 g) is added to dry cyclopentanol (50 mL) and the mixture refluxed for 4 hours. The mixture is concentrated, the residue dissolved in ethyl acetate (400 mL) and the ethyl acetate solution is washed with water (3×250 mL). After drying (MgSO4) the solution is evaporated to dryness to give cyclopentyl 6-chloro-5-methoxypyridine-2-carboxylate (6.3 g) as a buff solid, m.p. 90-92° C. [Elemental analysis: C, 55.9; H, 5.47; Cl, 13.9; N, 5.48%. calculated: C, 56.36; H, 5.52; Cl, 13.8; N, 5.48%.].

Provenance & Evidence