1,3-Dibromopropane → HCID 11210975, compound

Participants

Reaction Steps

Alternatively, the desired compound was prepared according to the method of Example 5D, starting with 4-(4-fluorophenyl)-3-hydroxy-5-(4-(methylsulphonyl)phenyl)-pyrazole and substituting 1,3-dibromopropane in place of 1,2-dibromo ethane (yield: 150 mg, 81%). MS (APCI+) m/z 373 (M+H)+; (APCI−) m/z 371 (M−H)−; 1H NMR (300 MHz, DMSO-d6) δ2.27 (m, 2H), 3.23 (s, 3H), 4.20 (t, J=7 Hz, 2H), 4.38 (d, J=7 Hz, 2H), 7.20 (m, 4H), 7.60 (d, J=9 Hz, 2H), 7.87 (d, J=9 Hz, 2H); Anal. calc. for C19H17FN2O3S; C, 61.27; H, 4.60; N, 7.52. Found: C, 60.93; H, 4.48; N, 7.34.

Provenance & Evidence