HCID 18409456, compound → HCID 18409478, compound

HRID 993321Notes

Reaction equation

HRID 993321 reaction equation
[CH3:1][C:2]([CH3:29])([CH3:28])[C:3](=[O:27])[CH2:4][O:5][C:6]1[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:9]([C:17]2[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[NH:8][N:7]=1.F[C:31]1C=CC(C2C(OCC(=O)C(C)(C)C)=NNC=2C)=C[CH:32]=1>O>[CH2:31]([N:8]1[C:9]([C:17]2[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:21][CH:22]=2)=[C:10]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:6]([O:5][CH2:4][C:3](=[O:27])[C:2]([CH3:29])([CH3:28])[CH3:1])=[N:7]1)[CH3:32]

Participants

4

Reactant 2

HCID 18409456HCID 18409456, compoundHCID 18409498HCID 18409498, compound

Product 1

HCID 18409478HCID 18409478, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The desired compound was prepared according to the method of Example 27, substituting 3,3-dimethyl-1-[(5-(4-(methylsulphonyl)phenyl)-4-phenyl-1H-pyrazol-3-yl)oxy]butan-2-one, prepared according to the method of Example 32B, in place of 1-[(4-(4-fluorophenyl)-5-methyl-1H-pyrazol-3-yl)oxy]-3,3-dimethylbutan-2-one (yield: 145 mg, 94%). MP 158-161° C.; MS (APCI+) m/z 441 (M+H)+; (APCI−) m/z 475 (M+Cl)−; 1H NMR (300 MHz, DMSO-d6) δ1.20 (m, 12H), 3.30 (s, 3H), 3.80 (q, J=7 Hz, 2H), 5.25 (s, 2H), 7.19 (m, 5H), 7.62 (d, J=9 Hz, 2H), 8.01 (d, J=9 Hz, 2H); Anal. calc. for C24H28N2O4S.0.25 H2O: C, 64.76; H, 6.45; N, 6.29. Found: C, 64.72; H, 6.60; N, 6.13.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-407a2d374ec949ad89429383e490806f
Source dataset
uspto-grants-2002_10
Patent number
US06472416B1

Reaction notes

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