Ammonia → HCID 11394995, compound

Participants

Reaction Steps

The desired product was prepared according to the method of Example 73D-73E substituting 1-bromo-2-butanone in place of 4′-fluoro-2-bromoacetophenone. The resulting thio-ether product was then oxidized as described in Example 73F (yield: 68 mg, 10%). MP 205-208° C.; MS (DCI-NH3) m/z 357(M+H)+, m/z 374 (M+NH4)+; 1H NMR (300 MHz, DMSO-d6) δ1.35 (t, J=7 Hz, 3H), 2.85 (q, J=7 Hz, 2H), 3.25 (s, 3H) 7.3 (m, 2H), 7.5 (m, 4H), 7.8 (d, J=9 Hz, 2H), 8.04 (s, 1H); Anal. calc. for C20H17FN2O3S: C, 62.49; H, 4.46; N, 7.29. Found C, 62.28; H, 4.36; N, 6.95.

Provenance & Evidence