Oxalic Acid → 2-[4-(4-Isopropoxymethyl-benzyl)-phenyl]-imidazoline oxalate

HRID 993372Notes

Reaction equation

HRID 993372 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH:7]([O:10][CH2:11][C:12]1[CH:29]=[CH:28][C:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[NH:24][CH2:25][CH2:26][N:27]=3)=[CH:19][CH:18]=2)=[CH:14][CH:13]=1)([CH3:9])[CH3:8]>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH:7]([O:10][CH2:11][C:12]1[CH:29]=[CH:28][C:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[NH:27][CH2:26][CH2:25][N:24]=3)=[CH:19][CH:18]=2)=[CH:14][CH:13]=1)([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 971Oxalic AcidHCID 218769092-[4-(4-Isopropoxymethyl-benzyl)-phenyl]-imidazoline

Product 1

HCID 218769822-[4-(4-Isopropoxymethyl-benzyl)-phenyl]-imidazoline oxalate

Procedure

Oxalic acid (129 mg, 1.43 mmol) was added to 2-[4-(4-isopropoxymethyl-benzyl)-phenyl]-imidazoline and recrystallized from acetone to give 2-[4-(4-isopropoxymethyl-benzyl)-phenyl]-imidazoline oxalate (507 mg) as a white crystalline solid, m.p. 156.3-156.7° C.; Analysis for C20H25N3O.C2H2O4: Calc.: C, 63.91; H, 6.58; N, 10.16; Found: C, 63.98; H, 6.53; N, 10.24.

Workup

  1. customrecrystallized from acetone

Sources & evidence

ORD record
ord-c57269e05c0b4db3bfa84693f0f86f87
Source dataset
uspto-grants-2002_10
Patent number
US06472536B1

Reaction notes

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