Benzaldehyde → 4-Aminomethyl-1-N-Cbz-piperidine

Participants

Reaction Conditions

Reaction Steps

22.2 g (0.2 mol) of 4-aminomethylpiperidine was dissolved in 250 ml of toluene and 21.2 g (0.2 mol) of benzaldehyde was added thereto. The reaction mixture was refluxed for 3 hours with Dean-stack to remove water, and then cooled down to 0° C. 34.2 g (0.2 mol) of benzylchloroformate was added slowly thereto while stirring. The mixture was stirred at room temperature for 3 hours and 220 ml of 1N aqueous KHSO4 solution was added thereto. The mixture was extracted three times with 200 ml of diethylether, and the aqueous layer was basified with 1N aqueous sodium hydroxide solution. The aqueous solution was saturated with sodium chloride. The aqueous layer was extracted three times with 100 ml of dichloromethane, dried over anhydrous magnesium sulfate and distilled under reduced pressure to give 38 g (Yield 91%, Molecular weight 248) of the title compound.

Provenance & Evidence