HCID 18409295, compound → HCID 18409182, compound

HRID 993472Notes

Reaction equation

HRID 993472 reaction equation
[CH2:1]([O:5][P:6]([O:35][CH2:36][CH2:37][CH2:38][CH3:39])([CH2:8]/[CH:9]=[CH:10]/[CH2:11][C:12]1([C:27]([NH:29][CH2:30][C:31]([F:34])([F:33])[F:32])=[O:28])[C:24]2[CH:23]=[C:22]([F:25])[CH:21]=[CH:20][C:19]=2[C:18]2[C:13]1=[CH:14][C:15]([F:26])=[CH:16][CH:17]=2)=[O:7])[CH2:2][CH2:3][CH3:4]>C(O)C.[Pd]>[CH2:36]([O:35][P:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])([CH2:8][CH2:9][CH2:10][CH2:11][C:12]1([C:27]([NH:29][CH2:30][C:31]([F:34])([F:33])[F:32])=[O:28])[C:13]2[CH:14]=[C:15]([F:26])[CH:16]=[CH:17][C:18]=2[C:19]2[C:24]1=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)=[O:7])[CH2:37][CH2:38][CH3:39]

Participants

4

Reactant 1

HCID 18409295HCID 18409295, compound

Product 1

HCID 18409182HCID 18409182, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of Example 203 compound (574 mg, 1 mmol) in 25 ml of absolute ethanol containing 250 mg of 10% Pd on carbon as catalyst was stirred under a hydrogen atmosphere (balloon) for 48 hours. The reaction was filtered after stirring 24 hrs and fresh catalyst added. The reaction was filtered through a 0.45 μm nylon filter and the solvent evaporated yielding 538 mg (94%) of title compound as a colorless oil.

Workup

  1. filtrationThe reaction was filtered
  2. additionfresh catalyst added
  3. filtrationThe reaction was filtered through a 0.45 μm nylon
  4. filtrationfilter
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-c2019c9cc75c40ed8ccd872dc11ad40d
Source dataset
uspto-grants-2002_10
Patent number
US06472414B1

Reaction notes

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