Succinic anhydride → HCID 178512849, compound

HRID 993480Notes

Reaction equation

HRID 993480 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([NH:8][C@H:9]([C:17](=[O:19])[NH2:18])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([NH2:16])=[NH:15])=[O:7])=[CH:4][C:3]=1[O:22][CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1[Cl:32].[C:33]1(=[O:39])[O:38][C:36](=[O:37])[CH2:35][CH2:34]1>>[C:17]([C@@H:9]([NH:8][C:6]([C:5]1[CH:20]=[CH:21][C:2]([NH:1][C:33](=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[C:3]([O:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=2[Cl:32])[CH:4]=1)=[O:7])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([NH2:16])=[NH:15])(=[O:19])[NH2:18]

Participants

3

Reactant 2

HCID 7922Succinic anhydrideHCID 178512848HCID 178512848, compound

Product 1

HCID 178512849HCID 178512849, compound

Procedure

The third part of the resin obtained in Example 2 (116 mg) was coupled with 160 mg of succinic anhydride analogously to the procedure described in Example 3. The resin was washed and dried, and the final product was cleaved off and processed as described in Example 1.

Workup

  1. washThe resin was washed
  2. customdried

Sources & evidence

ORD record
ord-7eb620a8c5354200b8e030b85c54c72d
Source dataset
uspto-grants-2002_10
Patent number
US06472562B1

Reaction notes

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