Acetonitrile → 2-(4-Fluorophenyl)-3-(pyrimidin-4-yl)-7-piperidin-4-ylimidazo[1,2-a]pyridine

HRID 99797Notes

Reaction equation

HRID 99797 reaction equation
[CH3:51][C:52]#[N:53].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([cH:12][cH:13][c:14]([CH:16]4[CH2:17][CH2:18][N:19]([C:22]([O:23][CH2:24][c:25]5[cH:26][cH:27][cH:28][cH:29][cH:30]5)=[O:31])[CH2:20][CH2:21]4)[cH:15]3)[c:32]2-[c:33]2[n:34][cH:35][n:36][cH:37][cH:38]2)[cH:6][cH:7]1.[I:46][Si:47]([CH3:48])([CH3:49])[CH3:50].[SH:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([cH:12][cH:13][c:14]([CH:16]4[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]4)[cH:15]3)[c:32]2-[c:33]2[n:34][cH:35][n:36][cH:37][cH:38]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 7969ThiophenolHCID 85247Trimethylsilyl iodideHCID 69210573Benzyl 4-[2-(4-fluorophenyl)-3-(pyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]-piperidine-1-carboxylate

Product 1

HCID 692084082-(4-Fluorophenyl)-3-(pyrimidin-4-yl)-7-piperidin-4-ylimidazo[1,2-a]pyridine

Sources & evidence

ORD record
ord-a58c83859244435f89b2e64ea2323f5f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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