3-(4-Methylpiperazin-1-yl)aniline → [3-(4-Methyl-piperazin-1-yl)-phenyl]-(8-{4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amine

HRID 99864Notes

Reaction equation

HRID 99864 reaction equation
[CH3:30][N:31]1[CH2:32][CH2:33][N:34]([c:37]2[cH:38][c:39]([NH2:40])[cH:41][cH:42][cH:43]2)[CH2:35][CH2:36]1.[CH:44]1([P:45]([CH:46]2[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][c:57]2-[c:58]2[cH:59][cH:60][cH:61][cH:62][c:63]2[P:64]([CH:65]2[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]2)[CH:71]2[CH2:72][CH2:73][CH2:74][CH2:75][CH2:76]2)[CH2:77][CH2:78][CH2:79][CH2:80][CH2:81]1.[Cl:1][c:2]1[n:3][n:4]2[c:5]([c:6](-[c:10]3[cH:11][cH:12][c:13]([N:16]4[CH2:17][CH2:18][CH:19]([N:22]5[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]5)[CH2:20][CH2:21]4)[cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:29]1>>[c:2]1([NH:40][c:39]2[cH:38][c:37]([N:34]3[CH2:33][CH2:32][N:31]([CH3:30])[CH2:36][CH2:35]3)[cH:43][cH:42][cH:41]2)[n:3][n:4]2[c:5]([c:6](-[c:10]3[cH:11][cH:12][c:13]([N:16]4[CH2:17][CH2:18][CH:19]([N:22]5[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]5)[CH2:20][CH2:21]4)[cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:29]1

Participants

4

Reactant 3

HCID 115646133-(4-Methylpiperazin-1-yl)anilineHCID 249469872,2'-Bis(dicyclohexylphosphino)-1,1'-biphenylHCID 674814222-Chloro-8-{4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 49838650[3-(4-Methyl-piperazin-1-yl)-phenyl]-(8-{4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amine

Sources & evidence

ORD record
ord-66db096f5ab54e5d9499d6e8ce84638c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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