Prop-2-en-1-yl {5-[5-(2-chloropyrimidin-4-yl)-2-(propan-2-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate → 5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

HRID 99903Notes

Reaction equation

HRID 99903 reaction equation
[Cl:1][c:2]1[n:3][c:4](-[c:5]2[s:6][c:7]([CH:8]([CH3:9])[CH3:10])[n:11][c:12]2-[c:13]2[cH:14][c:15]([NH2:19])[cH:16][cH:17][cH:18]2)[cH:20][cH:21][n:22]1.[Cl:23][c:24]1[n:25][cH:26][cH:27][c:28](-[c:30]2[c:31](-[c:38]3[cH:39][cH:40][c:41]([F:51])[c:42]([NH:44][C:45](=[O:46])[O:47][CH2:48][CH:49]=[CH2:50])[cH:43]3)[n:32][c:33]([CH:35]([CH3:36])[CH3:37])[s:34]2)[n:29]1>>[Cl:23][c:24]1[n:25][cH:26][cH:27][c:28](-[c:30]2[c:31](-[c:38]3[cH:39][cH:40][c:41]([F:51])[c:42]([NH2:44])[cH:43]3)[n:32][c:33]([CH:35]([CH3:36])[CH3:37])[s:34]2)[n:29]1

Participants

3

Reactant 2

HCID 53418796Prop-2-en-1-yl {5-[5-(2-chloropyrimidin-4-yl)-2-(propan-2-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamateHCID 579900463-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]aniline

Product 1

HCID 579897855-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

Sources & evidence

ORD record
ord-670d12bf60a846808d2a26e2a9e27034
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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