基本信息
- 标准SMILES
[Ca+2].[O-]Cl.[O-]Cl- InChIKey
ZKQDCIXGCQPQNV-UHFFFAOYSA-N- 分子式
- Ca(ClO)2
- 平均分子量
- 142.98 g/mol
- 单同位素质量
- 141.89012558
概述
Obtained by saturating calcium hydroxide (slaked lime) with chlorine.
名称与标识
- 首选名称
- Calcium hypochlorite
- IUPAC
- calcium dihypochlorite
- 中文名
- 次氯酸钙
- 英文名
- Calcium hypochlorite
- 分子式
- Ca.2ClHO
- 分子量
- 142.98
名称与别名
展开更多名称
数据库标识
- CAS
7778-54-3- PubChem CID
- 24504
- DTXSID
DTXSID1029700- ChEMBL
CHEMBL2251447- ChEBI
CHEBI:31342- UNII
- 11DXB629VZ
- EC Number
- 231-908-7
性质
结构计算性质
- 极性表面积
- 46.1 Ų
- 氢键供体
- 0
- 氢键受体
- 2
- 可旋转键
- 0
- 重原子
- 5
- 形式电荷
- 0
- 复杂度
- 2
实验与物化性质
Chemical Classes
Other Classes -> Inorganic Oxidizing Agents
Reactive agents - 1st degree
Density
2.350 g/cu cm
2.35 g/cm³
2.35 @25 °C
Color/Form
Powder
WHITE GRANULES OR PELLETS
White crystalline solid
Solubility
21% in water at 25 °C
Solubility in water, g/100ml at 25 °C: 21
Decomposition
The 70% grade may decomp violently if exposed to heat or direct sunlight. Gives off chlorine and chlorine monoxide above 350 °F (poisonous gases).
It will chemically decompose at temperatures above 212 °F to release chlorine and oxygen gas.
Dangerous; when heated to decomposition ... it emits highly toxic fumes of hydrogen chloride and explodes.
Decomposes at 100 °C
100 °C
Melting Point
100 °C
100 °C
Food Contact Substances
FCS -> FDA Cumulative Estimated Daily Intake (CEDI)
FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications
Physical Description
Obtained by saturating calcium hydroxide (slaked lime) with chlorine.
Calcium hypochlorite appears as a white granular solid (or tablets compressed from the granules) with an odor of chlorine. Toxic, irritating to the skin. Noncombustible, but will accelerate the burning of combustible materials. Prolonged exposure to fire or heat may result in the vigorous decomposition of the material and rupture of the container. Diluted samples may undergo reactions as described above if they contain less than 39% available chlorine but take longer to become involved and react less vigorously. Used for water purification, disinfectant for swimming pools, for bleaching paper and textiles.
Dry Powder
White solid granules with the odor of household bleaching powder; [CHRIS]
WHITE SOLID IN VARIOUS FORMS WITH PUNGENT ODOUR.
物理化学性质
- 熔点
- 100 °C · 100 °C(lit.)
- 密度
- 2.35 g/mL · 2.35 g/mL at 25 °C(lit.)
- 折射率
- 1.545 · 1.545
- 储存条件
- 15 °C · Store at +15°C to +25°C.
- 溶解度
- 200 g/l · 200g/l (decomposition)
- 形态
- Tablets
- 颜色
- White to off-white or faint green
- 比重
- 2.35 · 2.35
- 气味 (Odor)
- Chlorine-like odor
- 水溶解性
- 200 g/L · 200 g/L (20 ºC) (dec.)
- Merck
- 14 · 14,1674
- 介电常数
- 2.3 · 2.3(Ambient)
- 稳定性
- Stability Strong oxidizer - contact with flammable material may lead to fire. Incompatible with water, reducing agents, combustible material, phenol.
- 化妆品成分功效
- ANTIMICROBIAL
- InChI
- 1S/Ca.2ClO/c;2*1-2/q+2;2*-1
- InChIKey
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N
- SMILES
- ClO[Ca]OCl
- CAS 数据库
- 7778 · 7778-54-3(CAS DataBase Reference)
- EPA化学物质信息
- Calcium hypochlorite (7778-54-3)
化学性质
白色粉末。具有类似氯气的臭味。 溶解于水。
安全与法规
GHS分类
GHS Classification
Danger
H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]
P210, P220, P260, P264, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P378, P391, P405, and P501 (click each P-code to see the statement)
Danger
H271 (12%): May cause fire or explosion; strong Oxidizer [Danger Oxidizing liquids; Oxidizing solids]
P210, P220, P260, P264, P270, P273, P280, P283, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P321, P330, P363, P370+P378, P371+P380+P375, P391, P405, P420, and P501 (click each P-code to see the statement)
危害信息
Regulatory Information
Chemical: Hypochlorous acid, calcium salt
Hypochlorous acid, calcium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hypochlorous acid, calcium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: No longer Valid Update: 15-08-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/1611
Calcium hypochlorite, hydrated, with not less than 5.5% but not more than 16% water: Does not have an individual approval but may be used under an appropriate group standard
The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT Label
Oxidizer
Oxidizer
Fire Hazards
Excerpt from ERG Guide 140 [Oxidizers]:
Excerpt from ERG Guide 140 [Oxidizers]:
CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).
CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).
CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).
CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).
Fire Potential
Contact with combustible materials will increase fire hazard. May undergo accelerated decomposition with release of heat above 350 °F (177 °C). /Calcium hypochlorite, dry, or calcium hypochlorite, mixtures, dry/
Contact of solid hypochlorite with glycerol, digol monomethyl ether, or phenol causes ignition within few minutes, accompanied by irritant smoke, particularly with phenol (formation of chlorophenols).
Contents of a drum /of calcium hypochlorite/ erupted & ignited during intermittent use. This was attributed to contamination of soldered metal scoop (normally kept in the drum) by oil, grease or water, or all three, & subsequent exothermic reaction with the ... /hypochlorite/.
... The hypochlorite constitutes a hazard in the absence of other combustible materials, because after initiation, local rapid thermal decomp will spread through the contained mass of hypochlorite as a vigorous fire which evolves, rather than consumes, oxygen.
May cause fire in contact with wood or straw.
Not flammable /SRP: Acts as oxidizer with combustible material./
Health Hazards
Excerpt from ERG Guide 140 [Oxidizers]:
Excerpt from ERG Guide 140 [Oxidizers]:
· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.
· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.
· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.
· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.
Hazards Summary
An oxidizer that promotes combustion; Decomposes in the presence of heat, water, or contamination with release of corrosive chlorine gas; Calcium hypochlorite solutions are corrosive to the skin, eyes, and upper respiratory tract; [CHEMINFO] See Hypochlorous acid.
DOT ID and Guide
2208 140
2880 140
2208 140
1748 140
Reactive Group
Bases, Strong
Salts, Basic
Special Reports
Canelli E; Chemical, bacteriological and toxicological properties of cyanuric acid and chlorinated isocyanurates as applied to swimming pool disinfection: a review; Am J Public Health 64: 155-62 (1974). Review of bacteriological and toxicological properties of swimming pool disinfectants.
USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Sodium and Calcium Hypochlorite Salts (February 1992). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of August 29, 2013: http://www.epa.gov/oppsrrd1/REDs/old_reds/case0029.pdf]
安全与防护
Fire Fighting
Excerpt from ERG Guide 140 [Oxidizers]:
Excerpt from ERG Guide 140 [Oxidizers]:
NO powder. Use water in large amounts. In case of fire: keep drums, etc., cool by spraying with water.
First Aid Measures
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .
Accidental Release Measures
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· Keep combustibles (wood, paper, oil, etc.) away from spilled material.
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· Keep combustibles (wood, paper, oil, etc.) away from spilled material.
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· Keep combustibles (wood, paper, oil, etc.) away from spilled material.
First Aid
Excerpt from ERG Guide 140 [Oxidizers]:
Excerpt from ERG Guide 140 [Oxidizers]:
General First Aid:
General First Aid:
General First Aid:
General First Aid:
Exposure Control and Personal Protection
· Wear positive pressure self-contained breathing apparatus (SCBA).
· Wear positive pressure self-contained breathing apparatus (SCBA).
· Wear positive pressure self-contained breathing apparatus (SCBA).
· Wear positive pressure self-contained breathing apparatus (SCBA).
Fire Fighting Procedures
If material involved in fire: Extinguish using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Chlorinated lime, liquid/
Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Chlorinated lime, liquid/
Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Use flooding quantities of water as fog or spray. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. Do not use dry chemical fire extinguishers containing ammonium compounds. /Calcium hypochlorite, dry, or calcium hypochlorite, mixtures, dry/
Storage Conditions
Store in a cool, dry, well-ventilated location at a temperature below 120 °F (50 °C) to avoid slow decomposition. Separate from oxidizing materils, acids, ammonia, amines, and other chlorinating agents. Immediately remove and properly dispose of any spilled material. /Calcium hypochlorite, dry or calcium hypochlorite, mixtures, dry/
The bulk material may ignite or explode in storage. Traces of water may initiate the reaction.
Well closed. Store in an area without drain or sewer access. Separated from food and feedstuffs.
Cleanup Methods
Personal protection: chemical protection suit, face shield and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered air-tight, dry containers. Then store and dispose of according to local regulations.
Nonfire Spill Response
Excerpt from ERG Guide 140 [Oxidizers]:
Excerpt from ERG Guide 140 [Oxidizers]:
Disposal Methods
Dissolve the material in water and add to a large vol of concn reducing agent soln, then acidify the mixture with H2SO4. When reduction is complete, soda ash is added to make the soln alkaline. The alkaline liquid is decanted from any sludge produced, neutralized, and diluted before discharge to a sewer or stream. The sludge is landfilled.
毒理信息
Ecotoxicity Values
LC50; Species: Colinus virginianus (Northern bobwhite quail) age 9 days; diet >5620 ppm for 8 days
LC50; Species: Anas platyrhynchos (Mallard duck) age 10 days; diet >5620 ppm for 8 days
LD50; Species: Anas platyrhynchos (Mallard duck) age 25 weeks; oral via capsule >105 mg/kg
LD50; Species: Colinus virginianus (Northern bobwhite quail) age 27 weeks; oral via capsule; oral via capsule 1502 mg/kg (95% confidence interval: 1097-2561 mg/kg)
For more Ecotoxicity Values (Complete) data for CALCIUM HYPOCHLORITE (64 total), please visit the HSDB record page.
Ecotoxicity Excerpts
/AQUATIC SPECIES/ The aquatic effect of calcium hypochlorite in the environment, where pH value is supposed to range from 6 to 8, is common to other hypochlorite-generating chemicals like chlorine gas or sodium hypochlorite. The biologically significant chemical species are hypochloric acid or hypochlorite ion. /Hypochlorite/
Signs and Symptoms
Burning sensation. Sore throat. Wheezing. Laboured breathing. Shortness of breath.
Redness. Pain. Serious skin burns. Blisters.
Redness. Pain. Blurred vision. Severe deep burns.
Abdominal pain. Burning sensation. Shock or collapse.
Human Toxicity Excerpts
/SIGNS AND SYMPTOMS/ Symptomatology: 1. Pain & inflammation of mouth, pharynx, esophagus, & stomach. Erosion of mucous membranes, chiefly of stomach. 2. Vomiting ... hemorrhage ... 3. Circulatory collapse, with cold & clammy skin, cyanosis, & shallow respirations. 4. Confusion, delirium, coma. 5. Edema of pharynx, glottis & larynx, with stridor & obstruction. 6. Perforation of esophagus or stomach, with mediastinitis or peritonitis. 7. Inhalation of hypochlorous acid fumes causes severe resp tract irritation & pulmonary edema. 8. Skin contact may cause vesicular eruptions and eczematoid dermatitis. Hypochlorite/
/SIGNS AND SYMPTOMS/ When excess of calcium hydroxide is present, chlorinated lime is strongly alkaline & capable of causing lime burn of the eye. /Chlorinated lime/
/SIGNS AND SYMPTOMS/ ... Inhalation of /chlorinated lime/ fumes may cause laryngeal & pulmonary irritation, pulmonary edema, death. /Chlorinated lime/
/SIGNS AND SYMPTOMS/ Inhalation of dusts /bleaching powder/ may damage teeth, conjunctiva, & resp tract. If used as paste with excessive rubbing for more than 3 to 4 min ... sometimes causes moderate to severe ... damage to skin. /Bleaching powder/
For more Human Toxicity Excerpts (Complete) data for CALCIUM HYPOCHLORITE (13 total), please visit the HSDB record page.
Non-Human Toxicity Excerpts
/LABORATORY ANIMALS: Acute Exposure/ Wister-derived albino rats were dosed by gavage (vehicle: water) at 890, 1000, 1120, and 1260 mg/kg bw (10 males/group). Eight/10, 5/10, 9/10, and 10/10 deaths occurred at 890, 1000, 1120, and 1260 mg/kg, respectively. Moderate depression of the central nervous system was found at 1 hour after administration. Most survivors showed a mild to moderate persistent anorexia. Most affected animals showed diarrhea for several days. The LD50 was calculated to be 790 mg/kg.
/LABORATORY ANIMALS: Acute Exposure/ Exptl application of 5% aq soln of ... calcium hypochlorite, pH 11.5, to eyes of rabbits for thirty sec, followed by irrigation with water, caused superficial loss of epithelium from corneas & conjunctivas ... within a day corneas healed & conjunctivae were normal except for slight residual hyperemia. ...
/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ /NOAEL of 160 mg/kg was observed in a repeated dose oral toxicity studies in rats after exposure for 30 days./
/GENOTOXICITY/ Chromosomal aberrations were analyzed in Chinese hamster cells treated for 24 or 48 hours with three different doses of calcium hypochlorite, in the absence of metabolic activation. A positive increase in chromosomal aberrations was observed only in a culture treated with 0.5 ug/mL (6.7 mol/L = approx. 3.5 umol/L active chlorine) for 48 hours.
/VETERINARY CASE REPORTS/ Poisoning in animals ... as result of contamination of whey with hypochlorites used for disinfecting whey containers & from chlorinated lime (bleaching powder) used in error in limewash. Principal effect of such compounds, which yield chlorine in solution, is local irritation of the intestinal tract.
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence for the carcinogenicity of hypochlorite salts in experimental animals. No data were available from studies in humans on the carcinogenicity of hypochlorite salts. Overall evaluation: Hypochlorite salts are not classifiable as to their carcinogenicity to humans (Group 3). /Hypochlorite salts/
Probable Routes of Human Exposure
According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of calcium hypochlorite is 1 to 99; the data may be greatly underestimated(1).
NIOSH (NOES Survey 1981-1983) has statistically estimated that 82,721 workers (23,4896 of these were female) were potentially exposed to calcium hypochlorite in the US(1). The NOES Survey does not include farm workers. Occupational exposure to calcium hypochlorite may occur through inhalation and dermal contact with this compound at workplaces where calcium hypochlorite is produced or used. Monitoring data indicate that the general population may be exposed to calcium hypochlorite via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with consumer products containing calcium hypochlorite(SRC).
Routes of entry: Inhalation of dust. Inhalation of vapor and ingestion. /Chlorinated lime/
法规信息
FIFRA Requirements
Residues of the following materials are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Inert Ingredient: calcium hypochlorite; Use: sanitizing and bleaching agent.
Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Hypchlorous acid, calciuim salt is included on this list. Limit: When ready for use, the end-use concentration of all hypochlorous acid chemicals in the solution is not to exceed 200 ppm determined as total available chlorine.
Calcium hypochlorite is exempted from the requirement of a tolerance when used preharvest or postharvest in solution on all raw agricultural commodities. Calcium hypochlorite is exempted from the requirement of a tolerance in or on grape when used as a fumigant postharvest by means of a chlorine generator pad.
Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of relevant data concerning an active ingredient, whether products containing the active ingredient are eligible for reregistration. The Agency has previously identified and required the submission of the generic (i.e., active ingredient specific) data required to support reregistration of products containing ... calcium hypochlorite as a active ingredient. The Agency has completed its review of these generic data, and has determined that the data are sufficient to support reregistration of products containing ... calcium hypochlorite.
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Calcium hypochlorite is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0029; Pesticide type: fungicide, antimicrobial (bactericide); Registration Standard Date: 02/01/86; Case Status: RED Approved 09/91; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): calcium hypochlorite; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.
CERCLA Reportable Quantities
Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
Clean Water Act Requirements
Calcium hypochlorite is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.
安全数据
- wgk
- 2
- tsca
- TSCA listed
- 毒性
- LD50 orally in Rabbit: 850 mg/kg LD50 dermal Rabbit > 2000 mg/kg
- RTECS号
- NH3485000
- 包装类别
- II/III
- 危险等级
- 5.1
- 存储类别
- 5.1A - Strongly oxidizing hazardous materials
- 安全说明
- 26-36/37/39-45-61
- 海关编码
- 2828 10 00
- 危险品标志
- O,C,N
- 危险性类别
- Acute Tox. 4 OralAquatic Acute 1Eye Dam. 1Ox. Sol. 2Skin Corr. 1B
- 危险类别码
- 8-22-31-34-50
- 毒害物质数据
- 7778-54-3(Hazardous Substances Data)
- 危险品运输编号
- UN 2880
毒性防护
毒性本品粉尘和放出的氯气对呼吸道、皮肤和眼睛有强烈的刺激作用。如不慎溅入眼内,应立即用水冲洗。触及皮肤要用清水洗净,如皮肤被灼烧时应用稀硫代硫酸钠溶液和清水洗涤,并涂敷橄榄油。操作人员工作时要穿工作服,戴防毒口罩、密闭眼镜、乳胶手套等劳保用品。
急性毒性口服-大鼠 LD50: 850 毫克/公斤
包装储运
爆炸物危险特性遇水积热可爆
可燃性危险特性遇有机物可燃物发热可燃; 遇酸分解出助燃氧气; 高热分解有毒氯化物烟雾
储运特性库房通风干燥; 轻装轻卸; 与有机物、还原剂、硫磷易燃物分开存放
化学与工业
药理信息
Bionecessity
Hypochlorous ions are physiologically present in the human body, being formed by white blood cells (neutrophils and monocytes) as a powerful antimicrobial agent during inflammation process. When the recognition of "non-self" proteins in an invading micro-organism triggers the immune response, the enzyme myeloperoxidase located in mammalian neutrophils catalyses hypochlorous acid formation trough the oxidation of chloride ion in combination with hydrogen peroxide. The endogenously formed hypochlorous acid plays a key role in the process of phagocytosis through which bacteria are killed. Due to its potent cytotoxic action, hypochlorite is also responsible for neutrophil-mediated tissue damage associated with the inflammatory response. Its high efficiency as antimicrobial agent is associated with the lack of a catalytically active detoxifying mechanism for HOCl in both bacteria and mammalian cells. Although it has been suggested that HOCl-induced cytotoxicity can be associated to the degradation of a number of functionally important molecules the primary mechanism of action is still not fully elucidated. /Hypochlorite/
Mechanism of Action
Hypochlorous ions are physiologically present in the human body, being formed by white blood cells (neutrophils and monocytes) as a powerful antimicrobial agent during inflammation process. When the recognition of "non-self" proteins in an invading micro-organism triggers the immune response, the enzyme myeloperoxidase located in mammalian neutrophils catalyses hypochlorous acid formation trough the oxidation of chloride ion in combination with hydrogen peroxide. The endogenously formed hypochlorous acid plays a key role in the process of phagocytosis through which bacteria are killed. Due to its potent cytotoxic action, hypochlorite is also responsible for neutrophil-mediated tissue damage associated with the inflammatory response. Its high efficiency as antimicrobial agent is associated with the lack of a catalytically active detoxifying mechanism for HOCl in both bacteria and mammalian cells. Although it has been suggested that HOCl-induced cytotoxicity can be associated to the degradation of a number of functionally important molecules the primary mechanism of action is still not fully elucidated. /Hypochlorite/
Metabolism/Metabolites
It is well known from studies on HClO in inflammation processes that HClO is not enzymatically metabolised and its (bio)transformation readily occurs through direct reactions with organic compounds or with other chemicals present in the cellular environment, including hydrogen peroxide. The toxicokinetic study showed that chloride ion accounted for >80% (36)Cl radioactivity present in rat plasma. /Hypochlorite/
Absorption, Distribution and Excretion
Only ca. 50% is excreted mainly with the urine followed by excretion with feces. /Sodium hypochlorite/
Most of the data for toxicity of this substance by the oral route came from studies performed with sodium hypochlorite or chlorine gas. In biological systems, characterized by pH values in the range of 6-8, the most abundant active chemical species is HClO, in equilibrium with ClO-. Such available chlorine is readily absorbed via the oral route and distributed into plasma, bone marrow, testis, skin, kidney and lung. /sodium hypochlorite/
用途与制造
Uses
Used for swimming pool sanitation and other water treatment; Used in industries to disinfect, to control mildew, and to bleach textiles and paper; [CHEMINFO]
Pulp and Paper Processing [Category: Industry]
Disinfectant for drinking water and swimming pools; algicide; oxidizing agent; as household and industrial bleaching agent and sanitizer
Potable-water purification, bleaching agent (paper, textiles)
Calcium hypochlorite is used to cleanup hydrazine spills. Recommended procedure is discussed.
Chlorinated lime ... 2% strength ... used on grossly contaminated premises. Boric acid ... often used with it. Chlorinated lime/
Impurities
Commercial products normally contain various impurities such as CaCl2, CaCO3, Ca(OH)2 and water.
MgO, CaCO3, CaSO4, Al2O3, FeO3, and trace metals such as cobalt, nickel, copper and manganese.
Bromate was first reported as a disinfection by-product from ozonated waters, but more recently it has been reported also as a result of treatment using hypochlorite solutions worldwide. The aim of this study was to study the scope of this phenomenon in the drinking waters (n=509) of Castilla and Leon, Spain, and in the hypochlorite disinfectant reagents. Two thirds of the treated waters monitored were found to have bromate concentrations higher than 1 ug/L, and of them a median value of 8 ug/L and a maximum of 49 ug/L. These concentrations are higher than those reported so far, however, a great variability can be found. Median values for chlorite were of 5 ug/L, and of 119 ug/L for chlorate. Only 7 out of 40 hypochlorite feedstock solutions were negative for bromate, the rest showing a median of 1022 mg/L; and 4 out of 14 calcium hypochlorite pellets were also negative, the rest with a median of 240 mg/kg. Although bromate is cited as potentially added to water from calcium hypochlorite pellets, no reference is found in scientific literature regarding its real content. Chlorite (median 2646 mg/L) and chlorate (median 20,462 mg/L) and chlorite (median 695 mg/kg) and chlorate (median 9516 mg/kg) were also monitored, respectively, in sodium hypochlorite solutions and calcium hypochlorite pellets. The levels of chlorite and chlorate in water are considered satisfactory, but not those of bromate, undoubtedly owing to the high content of bromide in the raw brines employed by the chlor-alkali manufacturers. Depending on the manufacturer, the bromate concentrations in the treated waters may be very heterogeneous owing to the lack of specification for this contaminant in the disinfectant reagents -the European Norms EN 900 and 901 do not mention it.
U.S. Exports
(1984) 1.11X10+9 g
(1987) 4,382,677 lb
(1987) 512,096 lb /Calcium lime, chlorinated no more than 40% chlorine/
U.S. Imports
(1972) 9.07X10+8 G
(1975) 1.25X10+9 G
(1984) 4.02X10+9 g
(1986) 14,067,471 lb
(1986) 1,270,989 lb /Lime chlorinated with not more than 40% available chlorine/
U.S. Production
2023: 1,000,000 - <8,500,000 lb
(1972) 4.8X10+10 G
(1975) 6.36X10+10 G (DEMAND)
(1984) 5.04X10+9 g /est-based on export value equal to 22% of production/
Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#2416]
For more U.S. Production (Complete) data for CALCIUM HYPOCHLORITE (6 total), please visit the HSDB record page.
Consumption Patterns
Swimming pool sanitation and other bleaching and sanitation (municipal and industrial) uses, 78%; Exports, 22% (1986)
CHEMICAL PROFILE: Calcium hypochlorite. Residential swimming pool sanitation, 65%; municipal and industrial bleaching and sanitation, 15%; exports, 20%.
CHEMICAL PROFILE: Calcium hypochlorite. Demand: 1988: 120,000 tons; 1989: 122,000; 1993 /projected/: 132,000 tons. (Includes exports, but not imports, which totaled 6,000 tons last year.)
Residential swimming pool sanitation 75%, municipal and industrial bleaching and sanitation 25%.
For more Consumption Patterns (Complete) data for CALCIUM HYPOCHLORITE (6 total), please visit the HSDB record page.
Methods of Manufacturing
Chlorination of a slurry of lime and caustic soda with subsequent precipitation of calcium hypochlorite dihydrate, dried under vacuum.
... Chlorination of hydrated lime.
Drying a filter cake of neutral calcium hypochlorite dihydrate containing 30-50% water.
Formulations/Preparations
Grades: commercial (70%); high purity (99.2% available chlorine as calcium hypochlorite).
Chlorinated lime (bleaching powder)/ consists of mixt of ... calcium hypochlorite, calcium chloride, & calcium hydroxide; should not be confused with pure calcium hypochlorite. ...
Chloride of lime (35% calcium chlorine); highest calcium hypochlorite (70% available chlorine)
Chlorinated lime consists of a mixture of calcium chloride and calcium hypochloride and should contain a minimum of 30% available chlorine.
For more Formulations/Preparations (Complete) data for CALCIUM HYPOCHLORITE (130 total), please visit the HSDB record page.
General Manufacturing Information
Hypochlorous acid, calcium salt (2:1): ACTIVE
Chlorinated lime ... 20-30% soln ... needed for aporicidal action ... Concn kill trichuris (round worm) eggs. /Chlorinated lime/
The activity of this cmpd as a general disinfectant is based on its ability to release chlorine. In general, 5 1/2 oz ... (chlorine content from 20 to 27%) is mixed with each 50 lb of packing soil.
To disinfect feces, urine, and sanitary utensils; for purification of drinking water (1 oz to 2000 gal); for disinfection of swimming pool water (0.25 to 1 ppm of free chlorine); for removal of dyes from the skin. It is used as a household bleach. Chlorinated lime/
In freezing weather salt can be added as antifreeze without reducing benefits /calcium hypochlorites/.
For more General Manufacturing Information (Complete) data for CALCIUM HYPOCHLORITE (12 total), please visit the HSDB record page.
应用领域
简介漂白粉化学式CaCl2·Ca (ClO)2·2H2O,白色粉末状物质,其组成随制备条件不同而异,一般是次氯酸钙、氯化钙和未反应的氢氧化钙所组成的水合复盐,其有效成分为次氯酸钙。漂白粉具有很强的氧化性、腐蚀性和刺激性。遇水、乙醇或无机酸时均能发生分解,遇水或无机酸时分解为次氯酸,而次氯酸有很强的氧化、漂白和杀菌性能,故漂白粉的漂白作用主要是基于次氯酸的氧化性。
应用漂白粉可用于漂白棉、麻、纸浆,也是一种廉价有效的消毒剂、杀虫剂。
用途用于棉、麻、纸浆、丝纤维织物的漂白,饮用水、游泳池水等的杀菌和消毒,乙炔的净化等
用途主要用于棉织物、化学纤维、纸浆的漂白,也用于消毒、杀菌等
用途用作分析试剂、漂白剂、脱毛剂和氧化剂
用途用作棉、麻、纸浆、丝纤维织物的漂白,饮用水、游泳池水等的杀菌和消毒,乙炔的净化等
用途本品是高效漂白剂。常温下贮存200天以上不分解。主要用于棉麻、化纤、纸浆、淀粉的漂白。亦可用于饮用水、游泳池水的消毒和杀菌及皮革贮存中的防霉防腐剂。
用途是一种高效漂白剂。主要用于棉麻纺织品、化学纤维、纸浆、淀粉的漂白,也用于饮用水、游泳池水的消毒和杀菌。军工方面可用作化学毒剂(如芥子气等)和放射性的消毒剂。
用途主要用于造纸工业纸浆的漂白和纺织工业棉、麻、丝纤维织物的漂白。也用于城乡饮用水、游泳池水等的杀菌消毒。化学工业用于乙炔的净化,氯仿和其他有机化工原料的制造。可作羊毛防缩剂、脱臭剂等。
用途抗微生物剂;自来水净化剂;消毒剂;漂白剂。与漂白粉相同,但有效氯含量高。溶于水使用时,不溶性残渣少,性质稳定,有取代漂白粉的趋势。
用途消毒剂,漂白剂,脱臭剂,氧化剂。
制备方法
制备漂白粉可由氯气通入消石灰制得。其反应式如下:
生产方法氯气通入石灰乳而得,然后离心、干燥、粉碎而成。由氯气通入氢氧化钠和氢氧化钙的混合液而得。通称钠法。
生产方法吸收法先将石灰石与白煤按1:(0.11~0.13)的配比间断从石灰窑顶部加入石灰窑中进行煅烧,温度控制在800~1200℃,生成的石灰从窑底间断排出,将其加水消化,得到含有少量游离水的消石灰,陈化8天以上,经绞龙送至风选系统除渣。而粉末状消石灰经旋风分离器进行气固相分离。含有3%~6%游离水分的细粒消石灰,经消石灰仓下的绞龙从氯化塔的第四层加入,氯气(液氯液化尾气)从氯化塔第一层通入,漂白粉成品由氯化塔第一层排出。其2Ca(OH)2+2Cl2→Ca(Ocl)2·CaCl2·2H2O从氯化塔排出的尾气,用液碱吸收后生成次氯酸钠,废气然后放空。
生产方法石灰乳氯化法 石灰石煅烧生成的石灰,经破碎、消化、风选、配浆送入氯化反应釜,通人氯气进行氯化反应生成漂粉精,再经离心分离、干燥、磨粉,制得漂粉精成品。其8Ca(OH)2+6C12→本品+3CaCl2+4H2O
生产方法将石灰投入石灰窑中燃烧成石灰。经粉碎后取1 430 kg投入消化器中,加水配浆后送入氯化反应器中,遇990 kg氯气,充分反应后离心分离,将固体物干燥,磨粉得产品。
上下游产品信息
上游原料
下游产品
试剂价格
- 042548 · 10g
- 次氯酸钙, tech.Calcium hypochlorite, tech. — 324元
- 30034 · 5kg
- 次氯酸钙Calcium hypochlorite, tech., granular, 65% available chlorine, Thermo Scientific Chemicals — 6149元
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