次氯酸钙 → HCID 22708344，化合物

HRID 353246

反应方程式

HRID 353246 反应方程式
[Cl:1][O-].[Ca+2].Cl[O-].[F:6][C:7]([F:21])([F:20])[O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[O:17][CH2:16][CH2:15][C:14]2=[O:19]>O.C(O)(=O)C.C(#N)C.O>[Cl:1][C:11]1[CH:12]=[C:13]2[C:18](=[C:9]([O:8][C:7]([F:6])([F:20])[F:21])[CH:10]=1)[O:17][CH2:16][CH2:15][C:14]2=[O:19]

参与物

6

反应物 2

HCID 24504次氯酸钙HCID 22708350HCID 22708350，化合物

产物 1

HCID 22708344HCID 22708344，化合物收率 87%

试剂、催化剂与溶剂 3

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 6342乙腈溶剂HCID 21899381Acetic acid--water (1/1)溶剂

实验过程

To a solution of calcium hypochlorite (15.4 g, 72.4 mmol) in water:acetic acid (65:5) was added a solution of 8-trifluoromethoxychroman-4-one (4.2 g, 18.1 mmol; from step (iv) above) in acetonitrile (20 mL), whereafter the reaction mixture was stirred overnight. The mixture was diluted with water and extracted with ether (3 times) and EtOAc (once). The combined organic layer was washed with water, dried (Na2SO4) and evaporated, yielding 4.2 g (87%) of the sub-tide compound.

后处理

  1. extractionextracted with ether (3 times) and EtOAc (once)
  2. washThe combined organic layer was washed with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated

来源与证据

ORD记录
ord-043020b1396d4c3b960816fe83620a9d
来源数据集
uspto-grants-2004_06
专利号
US06750243B1

关联笔记

加载中…