二异丙基氨基锂 (HCID 2724682)

名称与标识

首选名称: Lithium diisopropylamide
IUPAC: lithium di(propan-2-yl)azanide
中文名: 二异丙基氨基锂
英文名: Lithium diisopropylamide
分子式: C6H16LiN
分子量: 109.14

名称与别名

Lithium diisopropylamide4111-54-0lithiodiisopropylamine2-Propanamine, N-(1-methylethyl)-, lithium saltEINECS 223-893-0EC 223-893-0diisopropylamine lithium salt2-Propanamine, N-(1-methylethyl)-, lithium salt (1:1)DTXSID6063305DIISOPROPYLAMINE LITHIUM SALT [MI]RefChem:799533DTXCID4039863

展开更多名称

二异丙胺锂二異丙胺鋰二异丙胺基锂异丙基氨基锂二异丙氨基锂二异丁基氨基锂二异丙基胺基锂二异丙基氨基锂二异丙胺锂,溶液二异丙基胺, 锂盐LDALithium saltLITHIUM DIISOPROPYLAMINElithium,di(propan-2-yl)azanidelithium diisopropylamide (LDA)Lithium diisopropylamide solutionDIISithium diisopropyLLithiuM diisopropylaMidLITHIUM DIISOPROPYLAMIDE THF COMPLEX

2Propanamine, N(1methylethyl), lithium salt223-893-0UNII-OL028KIW1IOL028KIW1Ilithium;di(propan-2-yl)azanideC6H14LiNMFCD00064449Lithium di-isopropyl amide

数据库标识

CAS: 4111-54-0
PubChem CID: 2724682
DTXSID: DTXSID6063305
UNII: OL028KIW1I
EC Number: 223-893-0
Nikkaji: J224.914F

性质

结构计算性质

极性表面积: 1 Å²
氢键供体: 0
氢键受体: 1
可旋转键: 2
重原子: 8
形式电荷: 0
复杂度: 37.8

实验与物化性质

Chemical ClassesMetals -> Organic Compounds, Metal Salts

Density0.79 @25 °C

Physical Description · 2 条

Wet Solid

Solid; [Merck Index]

物理化学性质

熔点: 6 · decomposes [MER06]
沸点: 65 °C · 65 °C
密度: 0.864 g/mL · 0.864 g/mL at 25 °C (lit.)
蒸气密度: 1 · >1 (vs air)
闪点: 91 °F · 91 °F
储存条件: 2 · 2-8°C
溶解度: soluble in ethyl ether; insoluble in hydrocarbon solvents
形态: liquid
颜色: brown
水溶解性: decomposes
敏感性: Air & Moisture Sensitive
Merck: 14 · 14,3196
BRN: 3655042 · 3655042
InChI: 1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1
InChIKey: ZCSHNCUQKCANBX-UHFFFAOYSA-N
SMILES: [Li]N(C(C)C)C(C)C
CAS 数据库: 4111 · 4111-54-0(CAS DataBase Reference)
EPA化学物质信息: 2 · 2-Propanamine, N-(1-methylethyl)-, lithium salt (4111-54-0)

安全与法规

GHS分类

GHS Classification · 4 条

Danger

H228 (15.4%): Flammable solid [Danger Flammable solids]

P210, P222, P231, P233, P240, P241, P260, P264, P264+P265, P280, P301+P330+P331, P302+P335+P334, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 208 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory Information · 5 条

Chemical: 2-Propanamine, N-(1-methylethyl)-, lithium salt

2-Propanamine, N-(1-methylethyl)-, lithium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propanamine, N-(1-methylethyl)-, lithium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 18-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/13825

2-Propanamine, N-(1-methylethyl)-, lithium salt: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryPyrophoric; Reacts with water evolving flammable gases that may spontaneously ignite; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Possible teratogen; [Sigma-Aldrich MSDS] See Diisopropylamine.

Hazard Classes and CategoriesFlam. Sol. 1 (15.4%)

安全与防护

Protective Action Criteria (PAC) · 3 条

2.5 [mg/m3]

28 [mg/m3]

170 [mg/m3]

毒理信息

Adverse EffectsDermatotoxin - Skin burns.

安全数据

F: 1-10
wgk: 3
tsca: TSCA listed
包装类别: I
危险等级: 4.2
存储类别: 3 - Flammable liquids
安全说明: 26-36/37/39-43-45-60-61-62-8-16-23-33-27
海关编码: 29211990
危险品标志: C,N,F
危险性类别: Aquatic Chronic 2Asp. Tox. 1Eye Dam. 1Flam. Liq. 2Repr. 2Skin Corr. 1BSTOT RE 1 InhalationSTOT SE 3
危险类别码: 14-17-34-67-65-51/53-35-19-15-11-50/53-14/15-10-40-23/24/25-62-63-37-48/20
危险品运输编号: UN 3399 4.3/PG 2

化学与工业

用途与制造

UsesUsed as a pH adjuster (perfumes) and in organic synthesis; [Merck Index]

U.S. Production2023: 50,000 - <250,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2 条

Pharmaceutical and Medicine Manufacturing

2-Propanamine, N-(1-methylethyl)-, lithium salt (1:1): ACTIVE

应用领域

应用二异丙基氨基锂在有机化学中通常作为碱被用于去质子化碳氢化合物。二异丙基氨基锂因可溶于非极性有机溶剂中，而被广泛应用。二异丙基氨基锂是有机合成中应用非常广泛的有位阻的非亲核性强碱试剂，在四氢呋喃中pKa = 35.7。在合成化学领域中常作为碱被用于去质子化碳氢化合物，有时还会用来生成碳负离子和烯醇负离子。

用途二异丙基氨基锂是非常有名的大位阻强碱，用于形成碳负离子。二异丙基氨基锂广泛应用于金属化碱性试剂，同时还应用于大位阻的非亲核性强碱试剂等。

试剂价格

26883 · 800ml: 二异丙基氨基锂，2M四氢呋喃/正庚烷/乙苯溶液Lithium diisopropylamide, 2M sol. in THF/n-heptane/ethylbenzene, AcroSeal™, Thermo Scientific Chemicals — 5139元
26883 · 100ml: 二异丙基氨基锂，2M四氢呋喃/正庚烷/乙苯溶液Lithium diisopropylamide, 2M sol. in THF/n-heptane/ethylbenzene, AcroSeal™, Thermo Scientific Chemicals — 1491元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

四川伟博贸易有限公司028-65199188 13880582998 · [email protected]

商丘市华康众邦生物科技有限公司13011705167

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二异丙基氨基锂

基本信息