碘甲烷 → 3,5-二氯-4-甲基吡啶

3,5-Dichloropyridine (2.04 g, 13.5 mmol) in THF (5 ml) was added dropwise to a solution of LDA [prepared from diisopropylamine (1.9 ml, 13.5 mmol) and n-butyllithium (1.6M, 8.4 ml, 13.5 mmol)] in THF (25 ml) at -70° C. After stirring at this temperature for 5 min, iodomethane (0.85 ml, 13.5 mmol) was added and the reaction mixture stirred for a further 1.5 h at -70° C. Saturated sodium hydrogen carbonate solution (20 ml) and dichloromethane (20 ml) was added and the organic phase separated, dried (MgSO4), and concentrated in vacuo. The residue was subjected to chromatography (SiO2 ; Et2O-hexane, 1:3) to afford the title compound (1.16 g) as a pale yellow solid; δH (CDCl3) 2.46 (3H, s, Me), and 8.36 (2H, s, pyridine H2, H6).

1. stirringthe reaction mixture stirred for a further 1.5 h at -70° C
2. customthe organic phase separated
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo

ORD记录

ord-ec4f0b3532d0429bb5eeb02f388b1e94

来源数据集

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

专利号

US05723460