乌苯美司 (HCID 72172)

名称与标识

首选名称: Ubenimex
IUPAC: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
中文名: 氨肽酶
英文名: Bestatin hydrochloride
分子式: C16H25ClN2O4
分子量: 344.83

名称与别名

BestatinUbenimex58970-76-6NK-421UbenimexumNK 421I0J33N5627NSC-265489((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine(3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine(S-(R*,S*))-N-(3-Amino-2-hydroxy-4-phenylbutyroyl)-L-leucineL-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, (S-(R*,S*))-

展开更多名称

氨肽酶盐酸倍他定盐酸贝他定苯丁抑制素贝他定盐酸贝他定盐酸盐贝他汀盐酸盐盐酸乌苯美司氨肽酶 1G乌苯美司盐酸盐Bestatin.HCIBESTATIN HCLUbenimex HClUbenimex-d7 HClUbenimex hydrochlorideHYDROCHLORIDE,UbenimexBestatin HCl - Bio-X ?Wufenmei HydrochlorideBestatin hydrochlorideBestatin research grade

(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acidNSC265489DTXSID4048430(2S)-2-(((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoic acidRefChem:9009613-amino-2-hydroxy-4-phenylbutyryl-L-leucine2-((3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoic acidDTXCID0028404

数据库标识

CAS: 58970-76-6、65391-42-6
PubChem CID: 72172
DTXSID: DTXSID301369975
ChEMBL: CHEMBL29292
UNII: I0J33N5627
EC Number: 261-529-2
Nikkaji: J12.831G

性质

结构计算性质

XLogP: -1
极性表面积: 113 Å²
氢键供体: 4
氢键受体: 5
可旋转键: 8
重原子: 22
形式电荷: 0
复杂度: 367

物理化学性质

熔点: 216 · 216-218 °C
储存条件: 2 · 2-8°C
溶解度: 2 O: · H2O: 25 mg/mL, clear, colorless
形态: White to off-white powder.
颜色: White
生物来源: synthetic (organic)
水溶解性: Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN: 4628066 · 4628066
稳定性: 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChI: 1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
InChIKey: XGDFITZJGKUSDK-UDYGKFQRSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]
CAS 数据库: 65391 · 65391-42-6(CAS DataBase Reference)

安全与法规

GHS分类

GHS Classification · 5 条

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危害信息

Hazard Classes and CategoriesSkin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (100%)

安全数据

F: 3-10
wgk: 3
存储类别: 11 - Combustible Solids
安全说明: 22-24/25-36-26
海关编码: 29242995
危险品标志: Xn
危险类别码: 20/21/22-36/37/38

化学与工业

药理信息

MeSH Pharmacological Classification · 6 条

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

Biologically active substances whose activities affect or play a role in the functioning of the immune system.

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.

Substances that inhibit the growth or reproduction of BACTERIA.

应用领域 · 3 条

概述氨肽酶，一类蛋白水解酶，它可以从蛋白或多肽链的N端由外向内逐个游离出氨基酸来，所以又称为肽链外切酶(expeptidase)，按其作用后的产物不同，分为两类，即生成氨基酸的α-氨酰肽水解酶(α-amino-acyl-peptide hydrolase)和生成二肽的二肽基肽水解酶(dipeptidyl-peptide hydrolase)；具有良好的水解能力和脱苦能力；可用作蛋白质序列测定的分子工具，在食品工业上通常与蛋白酶复合使用，广泛应用于调味品和奶酪的生产、蛋白水解液脱苦、蛋白质深度水解和多肽的制备等方面。

应用用于脱除蛋白水解液的苦味氨肽酶最显著的作用在于脱除蛋白水解液的苦味，如大豆蛋白水解液，多肽的苦味与其N端疏水性氨基酸的量成正比，外肽酶可以有效的切除这些疏水性氨基酸。蛋白质的深度水解与蛋白酶复合使用，可以大幅度提高蛋白质的水解度。在酱油酿造、干酪生产及其它蛋白水解产品的制备过程中，可以提高蛋白质的利用率，节省成本。如崔春、赵谋明等利用风味蛋白酶（蛋白酶和氨肽酶的复合体）深度酶解蓝园鱼参蛋白，酶解 6h 后蛋白质的利用率即达到 83.3%，21h 时水解度达到59.7%。生物活性多肽的制备生物活性多肽大部分是细胞生长因子，它们在体内含量极低，但生物活性极高，对多种细胞生理功能和代谢活动发挥着生物调节作用。具有保健和美容的功能。通过控制蛋白质的酶解来得到特定的活性肽是制备活性多肽的一种安全且高效的途径。刘通讯等先用蛋白酶对大豆分离蛋白进行水解，然后再用氨肽酶进行水解，研究发现，产品中的多肽含量相对单一用蛋白酶水解约能提高 12%左右。

应用可用作蛋白质序列测定的分子工具，在食品工业上通常与蛋白酶复合使用，广泛应用于调味品和奶酪的生产、蛋白水解液脱苦、蛋白质深度水解和多肽的制备等方面。

试剂价格

HY-B0134AR · 5 mg: 氨肽酶Bestatin hydrochloride (Standard) — 1440元
HY-B0134AR · 10 mg: 氨肽酶Bestatin hydrochloride (Standard) — 2220元

供应商50 家

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]

陕西缔都新材料有限公司81124267 17392282731 · [email protected]

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乌苯美司

基本信息