乌苯美司 → L-Leucine

HRID 1448156

反应方程式

HRID 1448156 反应方程式
[CH3:1][CH:2]([CH2:4][C@H:5]([NH:9]C([C@@H](O)[C@H](N)CC1C=CC=CC=1)=O)[C:6]([OH:8])=[O:7])[CH3:3]>Cl>[NH2:9][C@H:5]([C:6]([OH:8])=[O:7])[CH2:4][CH:2]([CH3:3])[CH3:1]

参与物

3

反应物 1

HCID 72172乌苯美司

产物 1

HCID 6106L-Leucine

试剂、催化剂与溶剂 1

HCID 313海萝胶溶剂

实验过程

The hydrolysis of bestatin in 6 N HCl at 100° C. for 18 hours yields L-leucine and an unusual amino acid. The ratio of these amino acids is 1:1. Bestatin gives positive Rydon-Smith and ninhydrin reactions. The amino acid sequence of bestatin shown in the structure was elucidated by fragmentation pattern in mass spectrum of bestatin methyl ester hydrochloride. Thus, the structure of bestatin is (2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine.

来源与证据

ORD记录
ord-40fb644ac47b47518b3d1cc593b69f10
来源数据集
uspto-grants-1979_12
专利号
US04179573

关联笔记

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