邻氨基对甲苯酚

2-Amino-4-methylphenol

HCID 7264CAS 95-84-1

基本信息

标准SMILES
Cc1ccc(O)c(N)c1
InChIKey
ZMXYNJXDULEQCK-UHFFFAOYSA-N
分子式
C7H9NO
平均分子量
123.15 g/mol
单同位素质量
123.06841391

概述

2-amino-4-methylphenol is a brown powder. (NTP, 1992)

名称与标识

首选名称
2-Amino-4-methylphenol
IUPAC
2-amino-4-methylphenol
中文名
邻氨基对甲苯酚
英文名
2-Amino-p-cresol
分子式
C7H9NO
分子量
123.15

名称与别名

2-Amino-4-methylphenol95-84-12-Amino-p-cresol2-Hydroxy-5-methylaniline3-Amino-4-hydroxytoluene6-Hydroxy-m-toluidine4-Methyl-2-aminophenolPhenol, 2-amino-4-methyl-5-Methyl-2-hydroxyanilinep-Cresol, 2-amino-DTXSID40244881-amino-2-hydroxy-5-methylbenzene
展开更多名称
邻氨基对甲酚邻氨基对甲苯酚2-氨基对甲酚对甲基邻氨基酚2-氨基对甲苯酚对甲基邻氨基苯酚邻氨基对甲基苯酚2-氨基-4-甲酚2-胺-4-甲苯酚2-氨基-4-甲苯酚O-AMINO-P-METHYLPHENOL2-AMINO-PARA-CRESOL, 97%CRESAMINEO-AMINO-P-CRESOL2-Amino-p-kresol
9ZV2574SER1-HYDROXY-2-AMINO-4-METHYLBENZENENSC-7630NSC-60737DTXCID804488RefChem:85218202-457-32-Amino-4-cresol

数据库标识

CAS
95-84-1
PubChem CID
7264
DTXSID
DTXSID4024488
ChEMBL
CHEMBL224282
ChEBI
CHEBI:39713
UNII
9ZV2574SER
EC Number
202-457-3
Nikkaji
J95.381D

性质

结构计算性质

XLogP
1.2
极性表面积
46.3 Ų
氢键供体
2
氢键受体
2
可旋转键
0
重原子
9

实验与物化性质

Chemical ClassesNitrogen Compounds -> Amino Phenols
DrugsPharmaceuticals -> Listed in ZINC15
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Boiling PointSublimes (NTP, 1992)
Melting Point279 °F (NTP, 1992)
Vapor Pressure0.00308 [mmHg]

物理化学性质

熔点
133 · 133-136 °C(lit.)
沸点
229.26 °C · 229.26°C (rough estimate)
密度
1.0877 · 1.0877 (rough estimate)
折射率
1.5706 · 1.5706 (estimate)
储存条件
Keep in dark place,Inert atmosphere,Room temperature
溶解度
slightly soluble

化学性质

外观为灰白晶体。 易溶于乙醇、乙醚、氯仿等有机溶剂。稍溶于水、苯。在热水中易溶。

安全与法规

GHS分类

GHS Classification · 5 条

This chemical does not meet GHS hazard criteria for 1.5% (1 of 65) of reports.

Warning

H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 65 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory Information · 2 条

Status: Active Update: 20-02-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/20332

Phenol, 2-amino-4-methyl-: Does not have an individual approval but may be used under an appropriate group standard

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available, however it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes and mucous membranes.
Hazards SummaryA skin, eye, and mucous membrane irritant; [NTP] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Reactive GroupPhenols and Cresols

安全与防护

Fire FightingFires involving this compound can be extinguished using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 条

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 条

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
Personal Protective Equipment (PPE) · 1 条

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

安全数据

wgk
2
tsca
TSCA listed
RTECS号
SJ6078000
存储类别
11 - Combustible Solids
安全说明
26-36-37/39
海关编码
29222900

毒性防护

急性毒性参考值: 腹腔-小鼠LD50: 680 毫克/公斤

包装储运 · 3 条

可燃性危险特性可燃;燃烧产生有毒氮氧化物烟雾

储运特性库房通风低温干燥

灭火剂干粉、泡沫、砂土、二氧化碳, 雾状水

化学与工业

用途与制造

UsesUsed as an intermediate for organic chemicals and dyes; [NTP]
General Manufacturing InformationPhenol, 2-amino-4-methyl-: ACTIVE

应用领域

用途用作染料中间体,也用于制取荧光增白剂

用途染料中间体,用于荧光增白剂DT等生产。

制备方法

生产方法邻硝基对甲苯酚用硫化碱或催化加氢还原而得。从对甲苯酚硝化出发原料消耗定额:对甲苯酚工业品963kg/t、硝酸(96%)661kg/t、硫酸(92.5%)2127kg/t、硫化碱(60%)2425kg/t、纯碱20kg/t。

试剂价格

A19546 · 250g
2-氨基-4-甲基苯酚, 98% 2-Amino-4-methylphenol, 98% — 689元
16321 · 50g
2-氨基对甲酚2-Amino-p-cresol, 97%, Thermo Scientific Chemicals — 292元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
爱斯特(成都)生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

相关反应

69 条

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