邻氨基对甲苯酚 → 5-Methyl-benzooxazole-2-carboxylic acid ethyl ester

HRID 29440

反应方程式

HRID 29440 反应方程式
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([O:12][C:13](OCC)([O:19]CC)[C:14](OCC)=O)[CH3:11]>>[CH2:10]([O:12][C:13]([C:14]1[O:9][C:3]2[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=2[N:1]=1)=[O:19])[CH3:11]

参与物

3

反应物 2

HCID 7264邻氨基对甲苯酚HCID 5090273三乙氧基乙酸乙酯

产物 1

HCID 687130605-Methyl-benzooxazole-2-carboxylic acid ethyl ester收率 91%

反应条件

温度
110 °C

实验过程

To 2-amino-4-methylphenol (1 g, 8.1 mmol) was added ethyl triethoxyacetate (5.4 g, 3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 850 mg (91%) of 5-methyl-benzooxazole-2-carboxylic acid ethyl ester as a white solid.

后处理

  1. temperatureThe reaction mixture was cooled
  2. customtriturated with hexane
  3. filtrationFiltration

来源与证据

ORD记录
ord-8b7b0d44b47645e18d89b4e26aef221a
来源数据集
uspto-grants-2008_09
专利号
US07420001B2

关联笔记

加载中…