三羟甲基氨基甲烷盐酸盐 (HCID 93573)

名称与标识

首选名称: Tromethamine hydrochloride
IUPAC: 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
中文名: 三羟甲基氨基甲烷盐酸盐
英文名: TRIS hydrochloride
分子式: C4H12ClNO3
分子量: 157.6

名称与别名

1185-53-1Tris hydrochlorideTris(hydroxymethyl)aminomethane hydrochlorideTromethamine hydrochloride2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochlorideTRIS HClTris-HClTrometamol hydrochlorideTrizma hydrochlorideTromethamine HCl1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideTris chloride

展开更多名称

三氯化氫盐酸氨丁三醇TRIS 盐酸氨丁三醇盐酸盐盐酸氨基丁三醇三羟基氨甲烷盐酸盐三羟基氨基甲烷盐酸盐三羟甲基氨基甲烷盐酸盐TRIZMA? 盐酸盐三甲醇氨基甲烷盐酸盐Tris-HCITRIS-HCL BUFFERTris-HCTRIS-HC1Tris hydrochloric acid

DTXSID4044373Tris hydrochloride bufferUNII-383V75M34EEINECS 214-684-5383V75M34E2-Amino-2-hydroxymethyl-1,3-propanediol hydrochlorideDTXCID2024373TROMETAMOL HYDROCHLORIDE [WHO-DD]

数据库标识

CAS: 1185-53-1
PubChem CID: 93573
DTXSID: DTXSID4044373
ChEMBL: CHEMBL3183206
UNII: 383V75M34E
EC Number: 214-684-5

性质

结构计算性质

极性表面积: 86.7 Å²
氢键供体: 5
氢键受体: 4
可旋转键: 3
重原子: 9
形式电荷: 0
复杂度: 54

实验与物化性质

Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other

Physical Description · 2 条

Dry Powder; Liquid; Other Solid; Dry Powder

Hygroscopic solid; [Sigma-Aldrich MSDS]

物理化学性质

熔点: 150 · 150-152 °C
沸点: 225 ℃[at · 225℃[at 101 325 Pa]
密度: 1.05 g/mL · 1.05 g/mL at 20 °C
蒸气压: 0 Pa · 0Pa at 20℃
储存条件: room temp
溶解度: 2 O: · H2O: 4 M at 20 °C, clear, colorless
形态: crystalline
颜色: clear colorless (40 % (w/w) in H2O) solution
PH值: 2.5 · 2.5-4.0 (25℃, 4M in H2O)
酸碱指示剂变色ph值范围: 7 · 7.0 - 9.0
酸度系数(pKa): 8.1 · 8.1(at 25℃)
生物来源: synthetic
水溶解性: SOLUBLE
最大波长(λmax): 260 nm · λ: 260 nm Amax: 0.12λ: 280 nm Amax: 0.08
敏感性: Hygroscopic
BRN: 3675235 · 3675235
稳定性: Stable. Incompatible with strong oxidizing agents, bases, moisture.
化妆品成分功效: ANTIMICROBIAL
InChI: 1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H
InChIKey: QKNYBSVHEMOAJP-UHFFFAOYSA-N
SMILES: Cl.NC(CO)(CO)CO
LogP: -3.6 at · -3.6 at 20℃
CAS 数据库: 1185 · 1185-53-1(CAS DataBase Reference)
EPA化学物质信息: 1 · 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1185-53-1)
Absorption: 0.05 at · ≤0.05 at 290nm at 40%

化学性质

白色结晶体。

安全与法规

GHS分类

GHS Classification · 5 条

This chemical does not meet GHS hazard criteria for 57.2% (103 of 180) of all reports.

Warning

H315 (42.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 180 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory Information · 4 条

Chemical: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 09-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19306

2-amino-2-(hydroxymethyl)propane-1,3-diol: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA mild eye irritant in rabbits; Not a sensitizer in experimental animals; [Sigma-Aldrich MSDS] See Tromethamine.

Hazard Classes and CategoriesSkin Irrit. 2 (42.2%)

安全与防护

Protective Action Criteria (PAC) · 3 条

18 [mg/m3]

190 [mg/m3]

1200 [mg/m3]

安全数据

F: 3
wgk: 3
tsca: TSCA listed
RTECS号: TY2900000
存储类别: 11 - Combustible Solids
安全说明: 26-36
海关编码: 29221980
危险品标志: Xi
危险类别码: 36/37/38

化学与工业

用途与制造

UsesUsed to make surface-active agents and pharmaceuticals, as an emulsifier (for cosmetic creams and lotions, mineral oil, and paraffin wax emulsions), as a biological buffer, and as an alkalizer; [ChemIDplus]

U.S. Production2023: 400,000 - <550,000 lb

Consumer UsesStabilizing agent

Industry UsesOther

General Manufacturing Information · 2 条

All Other Chemical Product and Preparation Manufacturing

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1): ACTIVE

应用领域 · 5 条

简介三羟甲基氨基甲烷盐酸盐简称Tris-HCl。三羟甲基氨基甲烷盐酸盐缓冲液（Tris-HCl缓冲液）不仅被广泛用作核酸和蛋白质的溶剂，还有许多重要用途。

应用三羟甲基氨基甲烷盐酸盐(Tris-HCl)被用于不同pH条件下的蛋白质晶体生长。Tris-HCL缓冲液的低离子强度特点可用于线虫（C. elegans）核纤层蛋白（lamin）的中间纤维的形成。Tris-HCl也是蛋白质电泳缓冲液的主要成分之一。此外，Tris-HCL还是制备表面活性剂、硫化促进剂和一些药物的中间物。Tris-HCl也被用作滴定标准物。

用途所有缓冲液的pH值依赖于温度和浓度。对于Tris 缓冲液,温度每增加1°C pH增加大约 0.03 单位, 每10倍的稀释pH减少0.03-0.05 单位。

用途用于生物缓冲液

用途用作有机合成中间体

上下游产品信息

下游产品

甘氨酸盐酸盐 2,2-二甲基-1,3-二恶烷-5-酮

试剂价格

J75893 · 500ml: te缓冲液TE Buffer, 1X Solution, Molecular Biology Grade, Ultrapure, Thermo Scientific Chemicals — 1558元
J75793 · 500ml: TE缓冲液TE Buffer, 1X Solution pH 8.0, Low EDTA, Molecular Biology Grade, Thermo Scientific Chemicals — 2856元