Halite (NaCl) → 2-(3,4-二羟基苯基)乙胺

HRID 5142

反应方程式

HRID 5142 反应方程式
C1C2(N(C3C=CC=CC=3)CNC2=O)CCN(CCC[C:21]([C:23]2[CH:28]=[CH:27][C:26](F)=CC=2)=[O:22])C1.C(O)[C:31](N)([CH2:34][OH:35])[CH2:32]O.Cl.[Na+].[Cl-].[Mg+2].[Cl-].[Cl-].CC([C@]1(O)C[C@H]2[N:51](C[C@H]3C4C2=CC=CC=4CCC2C=CC=CC3=2)CC1)(C)C>>[NH2:51][CH2:26][CH2:27][C:28]1[CH:32]=[CH:31][C:34]([OH:35])=[C:21]([OH:22])[CH:23]=1

参与物

6

反应物 5

HCID 5234Halite (NaCl)HCID 5265螺哌隆HCID 37461化合物 T23842HCID 93573三羟甲基氨基甲烷盐酸盐HCID 5360315氯化镁

产物 1

HCID 6812-(3,4-二羟基苯基)乙胺

实验过程

0.5 mL aliquots of the membrane preparation were incubated with unlabeled drugs, and 0.15 nM [3H]spiperone in a final volume of 1 mL containing 50 mM Tris HCl, 120 mM NaCl and 1 mM MgCl2 (pH 7.7). Nonspecific binding was measured in the presence of 100 nM (+)-butaclamol. After 15 minutes of incubation at 37° C., samples were filtered rapidly through Whatman GF/C glass filters under negative pressure, and washed three times with ice-cold binding buffer (5 mL).

后处理

  1. custom0.5 mL aliquots of the membrane preparation
  2. filtrationsamples were filtered rapidly through Whatman GF/C glass filters under negative pressure
  3. washwashed three times with ice-cold binding buffer (5 mL)

来源与证据

ORD记录
ord-29553a4becdf4d34adb98b5354444849
来源数据集
uspto-grants-1993_09
专利号
US05243048

关联笔记

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