二乙胺 → 5-(二乙基氨基)呋喃-2-甲醛

HRID 1018406

反应方程式

HRID 1018406 反应方程式
Br[C:2]1[O:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1.[CH2:9]([NH:11][CH2:12][CH3:13])[CH3:10]>CS(C)=O.CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-]>[CH2:9]([N:11]([CH2:12][CH3:13])[C:2]1[O:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1)[CH3:10]

参与物

5

反应物 2

HCID 8021二乙胺HCID 6003285-溴-2-呋喃甲醛

产物 1

HCID 7686385-(二乙基氨基)呋喃-2-甲醛收率 85%

试剂、催化剂与溶剂 2

HCID 21218甲基三辛基氯化铵催化剂HCID 679二甲基亚砜溶剂

实验过程

5-Bromofuraldehyde was dissolved in dimethylsulfoxide (DMSO) and 1-2 drops of Aliquart 336 (tricaprylylmethylammonium chloride, produced by Aldrich Co.) was added to the solution. 10 Equivalents diethylamine was added to the mixture and refluxed for 4 days. The remaining diethylamine was removed from the reaction mixture and subjected to extraction and column chromatography to obtain 5-diethylamino-2-furaldehyde with a yield of 85%.

后处理

  1. temperaturerefluxed for 4 days
  2. customThe remaining diethylamine was removed from the reaction mixture
  3. extractionsubjected to extraction and column chromatography

来源与证据

ORD记录
ord-abe686e4d26d4970b2b8826f02866b32
来源数据集
uspto-grants-2002_11
专利号
US06482494B2

关联笔记

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