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二乙胺 → 5-(二乙基氨基)呋喃-2-甲醛
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 二乙胺 | HCID 8021 | — |
| 反应物 | 5-溴-2-呋喃甲醛 | HCID 600328 | — |
| 催化剂 | 甲基三辛基氯化铵 | HCID 21218 | — |
| 溶剂 | 二甲基亚砜 | HCID 679 | — |
| 产物 | 5-(二乙基氨基)呋喃-2-甲醛 | HCID 768638 | 85% |
反应步骤
5-Bromofuraldehyde was dissolved in dimethylsulfoxide (DMSO) and 1-2 drops of Aliquart 336 (tricaprylylmethylammonium chloride, produced by Aldrich Co.) was added to the solution. 10 Equivalents diethylamine was added to the mixture and refluxed for 4 days. The remaining diethylamine was removed from the reaction mixture and subjected to extraction and column chromatography to obtain 5-diethylamino-2-furaldehyde with a yield of 85%.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US06482494B2 |
| 来源数据集 | uspto-grants-2002_11 |
| ORD ID | ord-abe686e4d26d4970b2b8826f02866b32 |
| 来源说明 | uspto-grants-2002_11 |