聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 3 -溴-6 -氯-2 -甲氧基吡啶

HRID 1054867

反应方程式

HRID 1054867 反应方程式
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:10][O-:11].[Na+].O>C(#N)C>[Br:1][C:2]1[C:3]([O:11][CH3:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1

参与物

5

反应物 3

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 10942334甲醇钠HCID 215518193-溴-2,6-二氯吡啶

产物 1

HCID 532174543 -溴-6 -氯-2 -甲氧基吡啶收率 93.2%

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.

后处理

  1. customthe organic was evaporated
  2. filtrationThe resulting suspension was filtered
  3. washthe pad was washed with water for several times
  4. customThe pad was dried

来源与证据

ORD记录
ord-6f02dd56485b4c9cbf12cee0cded4e36
来源数据集
uspto-grants-2016_07
专利号
US09394285B2

关联笔记

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