溴化氰 → [(3-Ethylphenyl)amino]carbonitrile

HRID 1069169笔记

反应方程式

HRID 1069169 反应方程式
[N:1]#[C:2]Br.[CH2:4]([C:6]1[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=1)[NH2:9])[CH3:5]>CCOCC>[CH2:4]([C:6]1[CH:7]=[C:8]([NH:9][C:2]#[N:1])[CH:10]=[CH:11][CH:12]=1)[CH3:5]

参与物

4

反应物 2

HCID 10476溴化氰HCID 114753-乙基苯胺

产物 1

HCID 10012043[(3-Ethylphenyl)amino]carbonitrile收率 96.5%

试剂、催化剂与溶剂 1

HCID 3283乙醚溶剂2 次

实验过程

A solution of cyanogen bromide (3.31 g, 31.26 mmol) in Et2O (25 ml) was added slowly to a stirred solution of m-ethylaniline (6.06 g, 50 mmol) in Et2O (50 ml) and continued stirring at room temperature for 6 hours. A white precipitate of m-ethylaniline hydrobromide (4.46 g) was filtered off, and the filtrate was washed with H2O (2×20 ml). Evaporation of ether layer afforded the title compound (3.85 g, 96.5%) as a thick liquid.

后处理

  1. filtrationA white precipitate of m-ethylaniline hydrobromide (4.46 g) was filtered off
  2. washthe filtrate was washed with H2O (2×20 ml)
  3. customEvaporation of ether layer

来源与证据

ORD记录
ord-9109bf362e0e4b3fa611fd10a9d0cdfc
来源数据集
uspto-grants-2001_06
专利号
US06251948B1

反应笔记

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