溴化苄 → Benzyl 3-hydroxytetradecanoate

HRID 1069255笔记

反应方程式

HRID 1069255 反应方程式
[OH:1][CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH2:3][C:4]([OH:6])=[O:5].C(N(CC)CC)C.[CH2:25](Br)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>CN(C=O)C>[OH:1][CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH2:3][C:4]([O:6][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:5]

参与物

5

反应物 3

HCID 7498溴化苄HCID 8471三乙胺HCID 160643-羟基肉豆蔻酸

产物 1

HCID 10520747Benzyl 3-hydroxytetradecanoate

试剂、催化剂与溶剂 1

HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

To a solution of 5.00 g of 3-hydroxymyristic acid in 50 ml of DMF were added at room temperature 2.85 ml of triethylamine and 2.43 ml of benzyl bromide. The reaction mixture was stirred at room temperature overnight. The solvent was removed in vacuo, ethyl acetate and water were added to the residue, and the organic layer was separated, washed twice with water and dried over anhydrous sodium sulfate. After the solvent was removed in vacuo, the crude product was purified by a silica gel column chromatography to afford 3.69 g of benzyl 3-hydroxymyristate (Intermediate 2).

后处理

  1. customThe solvent was removed in vacuo, ethyl acetate and water
  2. additionwere added to the residue
  3. customthe organic layer was separated
  4. washwashed twice with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customAfter the solvent was removed in vacuo
  7. customthe crude product was purified by a silica gel column chromatography

来源与证据

ORD记录
ord-a793d3b1b3ef4d3e974374fe0446f434
来源数据集
uspto-grants-2001_06
专利号
US06252041B1

反应笔记

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