2-溴乙醇 → -(+)-N-(2-羟乙基)-ALPHA-苯乙胺

HRID 1069402笔记

反应方程式

HRID 1069402 反应方程式
[CH3:1][C@@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12][OH:13]>ClCCl>[OH:13][CH2:12][CH2:11][NH:9][C@H:2]([CH3:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参与物

4

反应物 2

HCID 108982-溴乙醇HCID 643189R(+)-alpha-甲基苄胺

产物 1

HCID 6993821-(+)-N-(2-羟乙基)-ALPHA-苯乙胺收率 76,003%

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

反应条件

温度
51 °C

实验过程

51.45 g (0.43 mmole) of (R)-(+)-α-methylbenzylamine was dissolved in 52 ml of dichloromethane and 63.78 g (0.51 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 54 g of the title compound having pale yellow color.

后处理

  1. customthe reaction
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. distillationthe residue was subjected to fractional distillation

来源与证据

ORD记录
ord-f52640b0735f4828a029802ddd5ff12a
来源数据集
uspto-grants-2001_06
专利号
US06252076B1

反应笔记

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