异丙醇 → trans-1-Benzyl-3-hydroxymethyl-4-(2-methoxyphenyl)pyrrolidine

HRID 1070

反应方程式

HRID 1070 反应方程式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([N:14]1[CH2:18][C@@H:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH3:26])[C@H:16]([C:27](OC)=[O:28])[CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(O)(C)C.[Cl-].[Na+]>O1CCCC1>[CH2:7]([N:14]1[CH2:18][C@@H:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH3:26])[C@H:16]([CH2:27][OH:28])[CH2:15]1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参与物

6

反应物 4

HCID 3776异丙醇HCID 5234Halite (NaCl)HCID 21226445Aluminium lithium hydrideHCID 67661645Methyl [trans-1-benzyl-4-(2-methoxyphenyl)pyrrolidin-3-yl]carboxylate

产物 1

HCID 70344956trans-1-Benzyl-3-hydroxymethyl-4-(2-methoxyphenyl)pyrrolidine

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂2 次

反应条件

温度
5 °C

实验过程

To 560 mmol of lithium aluminum hydride in 800 ml of tetrahydrofuran (THF), under a nitrogen atmosphere and at 5° C., are added 225 mmol of methyl [trans-1-benzyl-4-(2-methoxyphenyl)pyrrolidin-3-yl]carboxylate (described in Preparation A) dissolved in 500 ml of THF. After stirring for 1 hour at 5° C., 139 ml of isopropyl alcohol are added slowly to the above mixture, followed by 85.2 ml of saturated sodium chloride solution. The mixture is stirred slowly at room temperature. After filtration and evaporation of the solvents, the expected product is obtained.

后处理

  1. customdescribed in Preparation A)
  2. stirringThe mixture is stirred slowly at room temperature
  3. filtrationAfter filtration and evaporation of the solvents

来源与证据

ORD记录
ord-aad0c6cdb96e435783b60b50f263f74c
来源数据集
uspto-grants-1998_03
专利号
US05723484

关联笔记

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