氯化亚锡 → 2-Chloro-4-hydrazinylbenzonitrile hydrochloride

HRID 1085

反应方程式

HRID 1085 反应方程式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([Cl:10])[CH:3]=1.[N:11]([O-])=O.[Na+].Cl[Sn]Cl>C1COCC1.O.Cl>[ClH:10].[Cl:10][C:4]1[CH:3]=[C:2]([NH:1][NH2:11])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

参与物

7

反应物 3

HCID 24479氯化亚锡HCID 887282-氯-4-氨基苯腈HCID 23668193亚硝酸钠

产物 1

HCID 221118492-Chloro-4-hydrazinylbenzonitrile hydrochloride

试剂、催化剂与溶剂 3

HCID 313海萝胶溶剂2 次HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 8028四氢呋喃溶剂

反应条件

温度
-5 °C

实验过程

5 g of 4-amino-2-chlorobenzonitrile and 40 ml of concentrated HCl in 30 ml of THF are mixed at -5° C.; 2.26 g of NaNO2 in 30 ml of water are added and the mixture is left stirring for 2 hours, 30 g of SnCl2 ·2H2O in 30 ml of concentrated HCl are then added and stirring is maintained at -5° C. for 30 minutes.

后处理

  1. waitthe mixture is left
  2. stirringstirring

来源与证据

ORD记录
ord-951984be58214825afaa7f028775b4b9
来源数据集
uspto-grants-1998_03
专利号
US05723483

关联笔记

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