盐酸 → HCID 66593501，化合物

HRID 1091663笔记

反应方程式

HRID 1091663 反应方程式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]#[N:12].[H-].[Na+].Cl[C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1.Cl>C1COCC1.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]1=[C:10]([C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1)[C:11]#[N:12]

参与物

7

反应物 4

HCID 313盐酸HCID 24758氢化钠HCID 744042-氯嘧啶HCID 342465苯并噻唑-2-乙腈

产物 1

HCID 66593501HCID 66593501，化合物

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 8028四氢呋喃溶剂

实验过程

2-(Benzothiazol-2-yl)acetonitrile (0.69 g, 4 mmol) was added in portions to a suspension of 95% sodium hydride ((0.21 g, 6 mmol) in THF (12 mL). The resulting yellow suspension was stirred at room temperature for 30 min, and 2-chloropyrimidine (0.45 g, 4 mmol) was added. The mixture was stirred for 3 d, and water was added to the dark solution. The mixture was acidified with 1N hydrochloric acid, and the precipitate that formed was collected by filtration, washed with water and acetonitrile, and dried under vacuum to give 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetonitrile as a brown solid.

后处理

  1. stirringThe mixture was stirred for 3 d
  2. customthe precipitate that formed
  3. filtrationwas collected by filtration
  4. washwashed with water and acetonitrile
  5. customdried under vacuum

来源与证据

ORD记录
ord-37ea5497767e4de7b014945facdd8c4a
来源数据集
uspto-grants-2012_03
专利号
US08129396B2

反应笔记

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