C.I.酸性橙108 → 1-(2-Hydroxyethylamino)-3-(2-hydroxyoctadecyloxy)-2-propanol

HRID 1095

反应方程式

HRID 1095 反应方程式
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH2:5]([O:9][CH2:10][CH:11]([OH:28])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:6]1[O:8][CH2:7]1>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH2:7][CH:6]([OH:8])[CH2:5][O:9][CH2:10][CH:11]([OH:28])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

参与物

4

反应物 2

HCID 700C.I.酸性橙108HCID 196946502-Hydroxyoctadecyl glycidyl ether

产物 1

HCID 196946271-(2-Hydroxyethylamino)-3-(2-hydroxyoctadecyloxy)-2-propanol收率 75.2%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂2 次

反应条件

温度
80 °C

实验过程

A 300-ml flask equipped with a stirrer, reflux tube and dropping funnel was charged with 40.5 g (0.66 mol) of ethanolamine and 8.6 g of ethanol. While heating and stirring the mixture at 80° C., an ethanol solution of 4.08 g (11.8 mmol) of 2-hydroxyoctadecyl glycidyl ether was added dropwise over 3 hours. After the resultant mixture was heated and stirred further for 3 hours, it was poured into 500 ml of ice water to collect crystals formed by filtration. The thus-obtained crystals were recrystallized again from n-hexane, thereby obtaining 3.58 g (yield: 75%) of the title compound (Ia-12).

后处理

  1. customA 300-ml flask equipped with a stirrer
  2. temperaturereflux tube
  3. temperatureWhile heating
  4. stirringstirred further for 3 hours
  5. customto collect crystals
  6. customformed by filtration
  7. customThe thus-obtained crystals were recrystallized again from n-hexane

来源与证据

ORD记录
ord-ab17bb46863940638ad69df37ccf3c23
来源数据集
uspto-grants-1998_03
专利号
US05723497

关联笔记

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