硼氢化钠 → (4-Bromo-7-methoxybenzofuran-2-yl)-methanol

HRID 1108317笔记

反应方程式

HRID 1108317 反应方程式
[BH4-].[Na+].[CH:3]([C:5]1[O:6][C:7]2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=[C:10]([Br:16])[C:8]=2[CH:9]=1)=[O:4]>C(O)CCC>[Br:16][C:10]1[C:8]2[CH:9]=[C:5]([CH2:3][OH:4])[O:6][C:7]=2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=1

参与物

4

反应物 2

HCID 4311764硼氢化钠HCID 187848644-Bromo-7-methoxy-1-benzofuran-2-carbaldehyde

产物 1

HCID 18784868(4-Bromo-7-methoxybenzofuran-2-yl)-methanol收率 86%

试剂、催化剂与溶剂 1

HCID 263丁醇溶剂

实验过程

Sodium borohydride (1.12 g) was added portionwise to a stirred solution of 2-formyl-4-bromo-7-methoxybenzofuran (30 g) in 1-butanol (150 ml) at ambient temperature. After stirring for 1 h the reaction was quenched by the addition of 2M hydrochloric acid (100 ml) and stirred overnight. The mixture was separated and the organic phase washed with water (200 ml). The combined aqueous phases were extracted with tert-butyl methyl ether (100 ml). The organic phases were combined and concentrated in vacuo followed by drying in vacuo at 60° C. to afford the title compound as a brown solid (26 g).

后处理

  1. customwas quenched by the addition of 2M hydrochloric acid (100 ml)
  2. stirringstirred overnight
  3. customThe mixture was separated
  4. washthe organic phase washed with water (200 ml)
  5. extractionThe combined aqueous phases were extracted with tert-butyl methyl ether (100 ml)
  6. concentrationconcentrated in vacuo
  7. customby drying in vacuo at 60° C.

来源与证据

ORD记录
ord-d7b26369c3a54cf6bc0c68d78ec08041
来源数据集
uspto-grants-2000_05
专利号
US06066657

反应笔记

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