(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 → 4-碘-3-甲基苯甲酸甲酯

HRID 1137

反应方程式

HRID 1137 反应方程式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH3:17]O>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([O:7][CH3:17])=[O:6]

参与物

4

反应物 3

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮HCID 1118四氧化硫HCID 15173221-(2-异丙基苯基)-2-硫脲

产物 1

HCID 2317574-碘-3-甲基苯甲酸甲酯

实验过程

24.4 g (0.093 mol) of 3-methyl-4-iodobenzoic acid and 250 ml of methanol were introduced into a round-bottomed flask and 2.5 ml of concentrated sulfuric acid were added dropwise. The mixture was heated at reflux for twelve hours, the reaction medium evaporated, taken up in ethyl acetate and water, the organic phase decanted off, dried over magnesium sulfate and evaporated. The residue was triturated in methanol and filtered; 21.9 g (85%) of the expected methyl ester of melting point 58°-59° C. were recovered.

后处理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for twelve hours
  3. customthe reaction medium evaporated
  4. customwater, the organic phase decanted off
  5. dry with materialdried over magnesium sulfate
  6. customevaporated
  7. customThe residue was triturated in methanol
  8. filtrationfiltered
  9. custom21.9 g (85%) of the expected methyl ester of melting point 58°-59° C. were recovered

来源与证据

ORD记录
ord-9664b54f4f6141978a503b896b8ef7fd
来源数据集
uspto-grants-1998_03
专利号
US05723499

关联笔记

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