乙酸铵 → 英文名称:9-AZABICYCLO[3.3.1]NONAN-3-AMINE, 9-METHYL-

HRID 1156539

反应方程式

HRID 1156539 反应方程式
[CH3:1][N:2]1[CH:7]2[CH2:8][CH2:9][CH2:10][CH:3]1[CH2:4][C:5](=[N:11]O)[CH2:6]2.C([O-])(=O)C.[NH4+]>C(O)C.[Ni]>[NH2:11][CH:5]1[CH2:4][CH:3]2[N:2]([CH3:1])[CH:7]([CH2:8][CH2:9][CH2:10]2)[CH2:6]1

参与物

5

反应物 2

HCID 517165乙酸铵HCID 3219133高托品酮肟

产物 1

HCID 14403175英文名称:9-AZABICYCLO[3.3.1]NONAN-3-AMINE, 9-METHYL-收率 90%

试剂、催化剂与溶剂 2

HCID 935Nickel催化剂HCID 702乙醇溶剂

实验过程

N-methyl-9-azabicyclo-[3.3.1]-nonan-3-one oxime (3.25 g., 0.02 mole) was dissolved in ethanol and hydrogenated over Raney nickel in the presence of ammonium acetate at 300 p.s.i. at 50° C. for 24 hours. The mixture was filtered, evaporated in vacuo, dissolved in dilute hydrochloric acid, basified and extracted into ethyl acetate. The combined organic layers were dried (K2CO3), filtered and evaporated in vacuo to yield 3-amino-9-methyl-9-azabicyclo-[3.3.1]-nonane (2.67 g., 90%), used without further purification.

后处理

  1. filtrationThe mixture was filtered
  2. customevaporated in vacuo
  3. dissolutiondissolved in dilute hydrochloric acid
  4. extractionextracted into ethyl acetate
  5. dry with materialThe combined organic layers were dried (K2CO3)
  6. filtrationfiltered
  7. customevaporated in vacuo

来源与证据

ORD记录
ord-6cef83b38483405fb5457d6b56a84acb
来源数据集
uspto-grants-1982_06
专利号
US04336259

关联笔记

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