2-氯甲基噻唑 → 2-Hydroxy-N-methyl-N-{2-[(4-{[3-methyl-4-(1,3-thiazol-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]ethyl}acetamide

反应方程式

[Cl:1][CH2:2][c:3]1[s:4][cH:5][cH:6][n:7]1.[OH:8][CH2:9][C:10](=[O:11])[N:12]([CH3:13])[CH2:14][CH2:15][O:16][c:17]1[c:18]2[c:19]([NH:27][c:28]3[cH:29][c:30]([CH3:35])[c:31]([OH:34])[cH:32][cH:33]3)[n:20][cH:21][n:22][c:23]2[cH:24][cH:25][cH:26]1>>[CH2:2]([c:3]1[s:4][cH:5][cH:6][n:7]1)[O:34][c:31]1[c:30]([CH3:35])[cH:29][c:28]([NH:27][c:19]2[c:18]3[c:17]([O:16][CH2:15][CH2:14][N:12]([C:10]([CH2:9][OH:8])=[O:11])[CH3:13])[cH:26][cH:25][cH:24][c:23]3[n:22][cH:21][n:20]2)[cH:33][cH:32]1

参与物

反应物 2

HCID 140908642-氯甲基噻唑

HCID 690579972-Hydroxy-N-[2-({4-[4-hydroxy-3-methylanilino]quinazolin-5-yl}oxy)ethyl]-N-methylacetamide

产物 1

HCID 113860592-Hydroxy-N-methyl-N-{2-[(4-{[3-methyl-4-(1,3-thiazol-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]ethyl}acetamide

来源与证据

ORD记录: ord-2f9f3e30c80a4c8f95772acceb41f377
来源数据集: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

反应笔记

加载中…