L-半胱氨酸 → HCID 14881540，化合物

HRID 129727笔记

反应方程式

HRID 129727 反应方程式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)=O.[NH2:15][C@H:16]([C:19]([OH:21])=[O:20])[CH2:17][SH:18]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[NH:15][CH:16]([C:19]([OH:21])=[O:20])[CH2:17][S:18]1

参与物

4

反应物 2

HCID 5862L-半胱氨酸HCID 880652-二吡啶基酮

产物 1

HCID 14881540HCID 14881540，化合物收率 11%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

A mixture of 3.68 g of di-2-pyridyl ketone, 2.42 g of L-cysteine, 25 ml of ethanol was refluxed for 3.5 hours. After allowing the mixture to cool, the insoluble matter was filtered off, and the filtrate was concentrated to dryness under reduced pressure. The residue was washed in sequence with ethyl acetate and ether to give 0.63 g of 2,2-di(2-pyridyl)-thiazolidine-4-carboxylic acid.

后处理

  1. temperaturewas refluxed for 3.5 hours
  2. temperatureto cool
  3. filtrationthe insoluble matter was filtered off
  4. concentrationthe filtrate was concentrated to dryness under reduced pressure
  5. washThe residue was washed in sequence with ethyl acetate and ether

来源与证据

ORD记录
ord-fbee9d5e5b41400f9f3691bf051546d4
来源数据集
uspto-grants-1995_11
专利号
US05470851

反应笔记

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